Multi-user Confocal Microscopy at Cornell University

该奖项支持购买共聚焦显微镜用于细胞和发育生物学的研究，由7名教师和他们的学生组成。 该设备也将提供给其他康奈尔大学的教师和学生，无论他们的部门关系的大量使用。激光共聚焦扫描显微镜由于其能够对活细胞的结构和过程进行非侵入性成像，并能够真实的实时观察大分子相互作用，因此已成为研究中至关重要和必不可少的工具。 计划的用途包括研究：调节植物内部和之间大分子运动的机制;细菌病原体假单胞菌与其宿主（番茄）的相互作用;生物膜的结构和功能;质体和线粒体在植物细胞生长和发育中的作用;离子通道的生理作用;以斑马鱼为模型的嗅觉系统的发展;以及果蝇中必需的生殖蛋白及其效应物的作用。预计这些研究和其他研究将对我们理解植物，动物和微生物中的大分子相互作用，细胞器生物发生和细胞重塑做出重要贡献。

This award supports the purchase of confocal microscope to be used for research in cell and developmental biology by a group of 7 faculty and their students. The equipment will also be available for use by a large number of other Cornell faculty and students, irrespective of their departmental affiliations. The confocal scanning laser microscope has become a critical and essential tool in research because of its ability to non-invasively image structures and processes in living cells, and visualize macromolecular interactions in real time. Among the planned uses are studies of: the mechanisms that regulate the movement of macromolecules within and between plants; the interactions of the bacterial pathogen Pseudomonas synringae with its host (tomato); the structure and function of biological membranes; the role of plastids and mitochondria in the growth and development of plant cells; the physiological roles of ion channels; the development of the olfactory system using zebrafish as a model; and the action of essential reproductive proteins and their effectors in Drosophila. It is expected that these and other studies will generate important contributions to our understanding of macromolecular interactions, organelle biogenesis and cellular remodeling in plants, animals and, as well, microbes.