GOALI: Experimental and Theoretical Studies on Compaction with Application on Pharmaceutical Powders

CMS-0100063压片的实验和理论研究与应用POWARMACEUTICAL POWDERSAntonios Zavaliangos和Iosif Csaba SinkaGOALI-NSF/CMS与药物设计的科学进步相比，片剂加工一直由经验主义主导，这是向新发现的市场过渡的瓶颈。在这个基础研究项目中，德雷克斯大学和默克公司的目标是为导致固体剂量的药物粉末的致密性建立科学基础。这项研究的具体目标是：(I)建立在具有工业操作特征的条件下对药物粉末进行表征的实验程序。(Ii)从实验上确定速率效应的来源及其对片剂机械性能的影响；(Iii)建立本构模型，准确描述粉末混合物在压制过程中的行为；(Iv)制定设计指南，以便在药物粉末配方中做出合理的决策。

CMS-0100063EXPERIMENTAL AND THEORETICAL STUDIES ON COMPACTION WITH APPLICATION ONPHARMACEUTICAL POWDERSAntonios Zavaliangos and Iosif Csaba SinkaGOALI - NSF/CMSIn contrast to the scientific advances in drug design, tablet processing hasbeen dominated by empiricism, and it presents a bottleneck for transition tomarket of new discoveries. In this basic research project, DrexelUniversity and Merck & Co., Inc. aim to develop a science basis for thecompaction of pharmaceutical powders that leads to solid dosages. Specificobjectives of this study are to: (i) establish experimental procedures forcharacterization of pharmaceutical powders under conditions characteristicof industrial operations. (ii) determine experimentally the origin of rateeffects and their influence on the mechanical properties of tablets, (iii)formulate constitutive models that portray accurately the behavior of powdermixtures during compaction, (iv) develop design guidelines that will allowrational decision making in pharmaceutical powder formulation.