Probing Metalloenzymes with Sensitizer-Linked Substrates

美国国家科学基金会化学部的无机、生物无机和金属有机化学计划支持加州理工大学贝克曼研究所的Harry Gray博士(Pi)和John Richards博士(co-Pi)的研究工作，开发和应用创新的“络合物内”电子转移反应，以研究氧化还原金属酶的反应路径，这是一系列具有重要生物学意义的蛋白质。有了这种支持，人们将对金属酶的化学有一个新的理解。拟议的基础研究的结果将显著增加跨越几个学科的知识库，并将显著影响生物和生化领域。学生和博士后助理将在各种实验技术方面获得宝贵的经验，并学习对跨学科方法的见解。

The Inorganic, Bioinorganic and Organometallic Chemistry Program of the Division of Chemistry, National Science Foundation, supports the research work of Dr. Harry Gray (PI) and Dr. John Richards (co-PI) of the Beckman Institute at Caltech to develop and apply innovative "intra-complex" electron transfer reactions to examine reaction pathways of redox metalloenzymes, a host of proteins that have significant biological relevance. With this support, a new understanding of the chemistry of metalloenzymes will be forthcoming. The results from the proposed fundamental study will significantly add to the knowledge base that will cut across several disciplines, and will impact markedly into biological and biochemical fields. Students and post-doctoral associates will gain invaluable experience in a variety of experimental techniques and learn insights into interdisciplinary methodologies.