Synthesis, Reactivity and Catalysis of Novel Metallacarboranes

加州大学洛杉矶分校化学和生物化学系M.Frederick Hawthorne在无机化学、生物无机化学和金属有机化学计划的支持下，继续对功能化碳硼烷的研究。碳硼烷的甲基化反应生成八甲基衍生物。这些甲基将被官能化，以得到具有所需性质的“带齿边碳硼烷”。甲基化碳硼烷将作为缺乏电子的过渡金属的配体进行研究，类似于五甲基环戊二烯。硼烷的直接羟基化提供了进入具有可调电子性质的其他新类型的硼原子簇的途径。碳硼烷和硼烷具有有趣的结构，并导致了对成键的新的见解。这项研究中所研究的官能化簇合物可能在水溶性催化、药物输送和分子电子学方面有应用。该项目集合成、表征和材料应用于一体，是培养学生的优秀项目。

M. Frederick Hawthorne, Department of Chemistry and Biochemistry, University of California Los Angeles, is continuing his research into functionalized carboranes with the support of the Inorganic, Bioinorganic and Organometallic Chemistry Program. Methylation of carboranes leads to octamethyl derivatives. These methyl groups will be functionalized to give "camoflagued carboranes" with desirable properties. The methylated carboranes will be studied as ligands for electron-deficient transition metals analogous to pentamethylcyclopentadienyl. Direct hydroxylation of boranes provides route into other new classes of boron clusters with tunable electronic properties.Carboranes and boranes have interesting structures and have led to new insights into bonding. The functionalized clusters studied in this grant may have applications in water-soluble catalysis, drug delivery, and molecular electronics. The project incorporates synthesis, characterization and materials applications, making it an excellent project for training students.