MRI: Acquisition of Digital High-Resolution NMR Equipment

在主要研究仪器(MRI)计划的这一奖励下，纽约大学化学系将获得一台400 MHz核磁共振(核磁共振)光谱仪，并升级现有500 MHz核磁共振光谱仪的控制台。该设备将使研究人员能够开展以下方面的研究：a)金属/配体构象动力学和在配位络合物中氧化/还原时螺旋手性元素的反转机理；b)维生素B12衍生物文库的制备；c)具有生物活性和理论意义的富勒烯加合物的表征；以及d)立体化学和DNA碱基序列对立体异构体苯并[a]芘二醇环氧化物与N-鸟嘌呤结合衍生的化学加合物构象迁移率的影响。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将在许多领域产生影响，包括材料化学和药物化学等。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at New York University will acquire a 400 MHz nuclear magnetic resonance (NMR) spectrometer and upgrade the console of an existing 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) metal/ligand conformational dynamics and the mechanism of inversion of an element of helical chirality upon oxidation/reduction in a coordination complex; b) the preparation of libraries of vitamin B12 derivatives; c) the characterization of biologically active and theoretically interesting fullerene adducts; and d) the impact of stereochemistry and DNA base sequence on the conformational mobility of chemical adducts derived from the binding of stereoisomeric benzo[a]pyrene diol epoxides to N2-guanine. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including materials chemistry and medicinal chemistry, among others.