QSB: Stable Heterologous Multi-Gene Expression: Insights from Hepatitis B Virus

该项目的长期目标是开发细胞环境如何影响基因表达和代谢网络反应的模型。 该方法需要探测和建模病毒如何重新定向宿主的代谢功能。 病毒“编码”了可管理的信息量，因此病毒宿主系统可能被证明是一个易处理的系统。 在对鸭乙型肝炎B（鸭）病毒的生长进行定量动力学研究后，将建立随机和确定性模型并进行对比。

The long range goal of this project is to develop models of how the cellular environment influences gene expression and metabolic network response. The approach entails probing and modeling how viruses can redirect metabolic function in a host. Viruses "encode" a manageable amount of information and thus a virus-host system may prove to be a tractable system. After performing quantitative kinetic studies of the growth of duck Hepatitis B (duck) virus, stochastic and deterministic models will be developed and contrasted.