Purchase of an HPLC ESI Mass Spectrometer

在化学研究仪器和设施(CRIF)计划的这一奖项下，加州大学欧文分校的化学系将获得一台高性能液体色谱仪-电喷雾电离质谱仪。该设备将加强下列领域的研究：a)非对映异构体多硅酸盐的分离和分析以及用于分离寡核苷酸和小肽的亲和力载体的评估(Shea)；b)用于蛋白质识别和功能研究的β-折叠模拟物的合成(Nowick)；c)天然产物合成的新策略和机理研究(Overman)；d)合成具有细胞毒性和抗真菌应用的高含氧大环内酯天然产物(Rychnovsky)；以及e)作为蛋白质结构探针的dityroine和ditritophan交联肽的合成(Van Vranken)。液-质联用(LC-MS)是一种用于复杂混合物的分离和分析的非常强大的技术。这一仪器的研究将在生物化学和药物化学等领域产生重大影响。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the University of California in Irvine will acquire a High Performance Liquid Chromatograph-Electrospray Ionization Mass Spectrometer. This equipment will enhance research in a number of areas including a) the separation and analysis of diastereomeric polysiliconates and the evaluation of affinity supports for the separation of oligonucleotides and small peptides (Shea); b) the synthesis of beta-sheet mimics for protein recognition and function research (Nowick); c) novel strategies and mechanistic studies for natural product synthesis (Overman); d) the synthesis of highly oxygenated macrolide natural products with potential cytotoxic and anti-fungal applications (Rychnovsky); and e) the synthesis of dityrosine and ditryptophan crosslinked peptides as protein structure probes (Van Vranken). Liquid chromatography with mass spectrometric detection (LC-MS) is an extremely powerful technique used for the separation and analysis of complex mixtures. The research that this instrument will enable will have a significant impact in the areas of biochemistry and pharmaceutical chemistry, among others.