The Development of New Olefin Metatheses-Based Processes

这项工作的目的是扩大烯烃复分解反应的范围和效用。 在PI先前工作的扩展中，将首先研究可用于交叉复分解反应的烯烃类型。 将研究官能化和环状烯烃的分子间交叉复分解，并将研究联烯和炔的开环复分解。 其次，将开发基于复分解的异构化反应，并使用这种方法实现聚烯烃环系统的新型骨架重排。 钌催化的对映选择性复分解异构化将探索除了顺序耦合的复分解反应与Kharasch反应，以建立更复杂的结构，在一个单一的反应烧瓶。有了这个奖项，有机和高分子化学计划是支持博士马克L。波士顿学院化学系的Snapper。Snapper博士将探索烯烃复分解反应的范围和实用性。 烯烃复分解是一种工业上重要的方法，用于从石油原料制备许多专用化学品和药物合成的起始材料。 开发更短，更环保的特种化学品路线（在用于影响键形成复分解反应的金属中具有催化作用）是拟议工作的一个可能结果。 在这项工作的过程中接受培训的学生将获得制药和特种化学工业所需的技能。

The objective of this work is to expand the scope and utility of olefin metathesis reactions. In an expansion of the PI's prior work, the types of olefins that can be used in cross metathesis reactions will first be investigated. Intermolecular cross metatheses of functionalized and cyclic olefins will be studied and the incorporation of allenes and alkynes into ring opening metatheses will be investigated. Secondly, metathesis based isomerization reactions will be developed and novel skeletal rearrangements of polyolefinic ring systems using this approach will be effected. Ruthenium catalyzed enantioselective metathesis isomerizations will be explored in addition to the sequential coupling of metathesis reactions with Kharasch reactions to build more complicated structures in a single reaction flask. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Marc L. Snapper of the Department of Chemistry at Boston College. Dr. Snapper will explore the scope and utility of olefin metathesis reactions. Olefin metathesis is an industrially important process used to make a number of specialty chemicals and starting materials for pharmaceutical syntheses from petroleum feedstocks. Developing shorter, more environmentally friendly routes to specialty chemicals (which are catalytic in metals used to effect the bond forming metathesis reactions) is one likely outcome of the proposed work. Students trained during the course of this work will gain skills needed by the pharmaceutical as well as specialty chemical industries.