The Development of Powerful New Ruthenium-Catalyzed Tandem Processes

这个项目的重点是更有效的协议，将简单的原料转化为更复杂和有价值的产品。该策略是使用单一的亚化学计量添加剂，可以在原位操作，催化两个或多个不同的转化在一个单一的反应容器，而不需要纯化中间产物之间的每一步。钌配合物催化的反应范围广泛，将研究几种一锅、多步骤的反应，包括烯烃易位反应/烯烃异构化、烯烃易位反应/自由基原子转移、易位反应/酮羟基化、易位反应/环加成和易位反应/环丙烷化。通过这个奖项，有机和大分子化学项目支持了波士顿学院化学系Marc L. Snapper教授的研究。斯内普教授和他的学生将研究串联反应、一锅反应和多步反应，以制备有机分子。这种串联工艺提高了整体合成效率，并在最大限度地减少时间、劳动力和材料成本方面具有优势。它们还最大限度地减少了废物的产生，从而实现了环保的制备过程。

This project is focused on more efficient protocols for converting simple starting materials into more complex and valuable products. The strategy is to use a single sub-stoichiometric additive that can be manipulated in situ to catalyze two or more distinct transformations in a single reaction vessel without the need to purify intermediates between each step. Ruthenium complexes, which are known to catalyze a wide range of reactions, will be studied to effect several one-pot, multi-step processes including olefin metathesis/olefin isomerization, olefin metathesis/radical atom transfer, metathesis/ketohydroxylation, metathesis/cyclo-addition, and metathesis/cyclopropanation. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor Marc L. Snapper of the Department of Chemistry at Boston College. Professor Snapper and his students will be investigating tandem, one pot, and multi-step reactions for the preparation of organic molecules. Such tandem processes improve overall synthetic efficiency and offer advantages in minimizing time, labor, and material costs. They also minimize waste production, leading to environmentally friendly preparation processes.