CAREER: The Development of New Matathesis-Based Processes

Snapper教授的研究主要集中在金属催化的亚烷基歧化反应的合成和机理研究上。考察了应变环烯的开环交叉复分解反应的范围，并探讨了该过程立体选择性的提高和对映体选择性交叉复分解反应的发展。使用底物控制的不对称合成，通过手性四烯的方法，以及通过使用手性Ru络合物的试剂控制，将被研究。还将研究概念上相关的光/热(2+2)/逆(2+2)环化途径。斯纳珀教授将开发一门本科研究课程，组建向当地学校提供化学演示和实验室设备的推广项目，并启动一个旨在提高研究生教学、口语、写作和组织技能的项目。有了这个职业奖，合成有机项目支持波士顿学院化学系的Marc L.Snapper教授的研究和教育活动。Snapper教授的研究针对的是使用金属催化的含有碳-碳双键的化合物的反应，即所谓的烯烃歧化反应，以影响各种类型有机产品的形成。通过改变反应中使用的特定结构，Snapper教授能够制备化合物，这些化合物可以作为合成与制药和生物技术行业相关的更复杂分子的方便起点。Snapper教授的教育活动包括提高本科生的研究经验，通过外展计划促进高中生对化学的兴趣，以及提高研究生的教学和沟通技能。

Professor Snapper's research focuses on synthetic and mechanistic studies of metal catalyzed alkylidene metathesis reactions. The scope of the ring-opening cross metathesis of strained cycloalkenes will be examined, and both improvement of the stereoselectivity of this process and development of enantioselective cross metathesis reactions will be explored. Asymmetric syntheses using substrate control, by means of chiral tetraenes, and reagent control, through use of chiral Ru complexes, will be examined. A conceptually related photo/thermal (2+2)/retro(2+2) cyclization pathway will also be investigated. Professor Snapper will develop an undergraduate research course, assemble outreach programs that will provide chemistry demonstrations and laboratory equipment to local schools, and initiate a program designed to improve the teaching, speaking, writing, and organizational skills of graduate students. With this CAREER award, the Synthetic Organic Program supports the research and educational activities of Professor Marc L. Snapper of the Department of Chemistry at Boston College. Professor Snapper's research is directed toward the use of a metal catalyzed reaction of compounds containing carbon-carbon double bonds, the so-called olefin metathesis reaction, to effect the formation of various types of organic products. By variation of the specific structures used in this reaction, Professor Snapper is able to prepare compounds which may serve as convenient starting points for the synthesis of more complex molecules of relevance to the pharmaceutical and biotechnology industries. Professor Snapper's educational activities involve enhancing the research experiences of undergraduates, facilitating the interest of high school students in chemistry through outreach programs, and improving the teaching and communication skills of graduate students.