CAREER: Reactive Low-Coordinate Compounds of the Late Transition Metals

罗切斯特大学化学系的帕特里克·霍兰德博士获得了国家科学基金会化学部无机、生物无机和有机化学项目的支持，他的工作获得了职业奖，利用配位化学发现了新的反应模式，并解决了酶、表面和溶液催化中的问题。 三配位过渡金属配合物将用于开发适用于金属蛋白质和催化剂的知识。 一个特别的重点是模拟还原不饱和有机化合物的酶固氮酶。 研究和教育将通过培训本科生参与研究工作，并将团队学习纳入罗切斯特大学的本科生和研究生无机化学课程中来整合。这项研究跨越生物学和化学催化等领域，重点关注配体不足的金属位点。 霍兰德博士的研究旨在从根本上了解这些位点的反应性，这将有助于了解酶的功能和开发新型催化剂。 在本科和研究生课程的团队学习将涉及化学作为一种社会活动，以更好地将科学融入他们的生活的学生。

Dr. Patrick Holland, Department of Chemistry, University of Rochester is supported by the Inorganic, Bioinorganic and Organometallic Chemistry program of the Division of Chemistry, National Science Foundation, for his work under a Career Award to utilize coordination chemistry to uncover novel modes of reactivity and address issues in enzymatic, surface and solution catalysis. Three-coordinate transition metal complexes will be used to develop knowledge applicable to metalloproteins and catalysts. A particular focus is on modelling the reduction of unsaturated organic compounds by the enzyme nitrogenase. Research and education will be integrated by training undergraduates to be involved in the research effort and incorporating team learning into undergraduate and graduate inorganic chemistry courses at the University of Rochester.This research cuts across such fields as biology and chemical catalysis and focuses on metal sites with less than a full complement of ligands. Dr. Holland's research aims at a fundamental understanding of the reactivity of such sites that will aid in understanding how enzymes function and in developing new types of catalysts. Team learning in undergraduate and graduate courses will involve students in chemistry as a social activity to better integrate science into their lives.