Informatics of Human and Monkey Brain Atlases

这个人脑计划将扩展我们以前在开发一个信息系统方面的努力，该系统可以存储、操作和检索由合作研究者汇编的大型数据集。该项目旨在管理从高分辨率人类和猴子大脑地图集、分子和细胞测绘研究、视网膜和丘脑细胞的形态测量学和生理学以及大脑连接研究中获得的数据。有一个行政核心负责监督、评估和传播，还有4个研究项目将收集数据，并在可视化和数据库中相互作用。项目1将设计和集成集成来自项目2-4的图形和非图形数据集的信息方法，并使用外侧膝状核作为模型，开发用于构建和维护神经科学特定数据库的软件工具，用于将来自项目2-4的各种信息集相互连接，以及用于网络检索和交换来自这些和其他神经科学数据集的信息。项目2将使用计算机辅助显微镜建立人类和猴子大脑的高分辨率数字图谱，扩展细胞结构以量化丘脑主要核中的神经元群（包括正常人、精神分裂症患者和躁狂抑郁症患者的大脑），以及它们的受体、化学定义的细胞和传入纤维系统的概况。这个项目包含了一个强大的可视化组件，由计算机科学家组成，他们在大型数据集的存储、操作和显示方面具有专业知识。它将建立一个中央神经图像库，并与其他项目密切合作，将开发用于操作、图形显示和浏览高分辨率组织学和神经化学脑地图集的软件工具，从横向膝状数据库开始，并使用互联网方法分发简化图像。项目3将扩展一个以形态学、化学、生理学和连接性为特征的视网膜细胞数据库，为横向膝状数据库提供模型和输入。项目4将开发一个猴子视觉丘脑-和皮质-皮质连接的数据库，以与侧膝状数据库整合，使用新开发的pulvinar数据库作为模型。

Jones, Edward G.0135396This Human Brain Project will extend our previous efforts in developing an information system that can store, manipulate and retrieve large datasets compiled by the collaborating investigators. The project is built around and designed to manage data obtained from high resolution human and monkey brain atlases, molecular and cellular mapping studies, morphometry and physiology of retinal and thalamic cells, and studies of brain connections. There is an Administrative Core responsible for oversight, evaluation and dissemination and 4 Research Projects that will collect data and interact in visualization and databasing. Project 1 will design and integrate informational methods that integrate graphical and non-graphical datasets derived from Projects 2-4 and, using the lateral geniculate nucleus as a model, will develop software tools for building and maintaining neuroscience specific databases, for linking the diverse information sets derived from Projects 2--4 to one another, and for network retrieval and interchange of information from these and other neuroscience datasets. Project 2 will use computer assisted microscopy to build high resolution digital atlases of human and monkey brains, extending cytoarchitecture to quantify neuronal populations in the major nuclei of the thalamus (including in normal, schizophrenic and manic depressive human brains), and their profile of receptors and chemically defined cells and afferent fiber systems. This project incorporates a strong Visualization Component made up of computer scientists who have expertise in storage, manipulation and display of large datasets. It will populate a central NeuroImage Repository and, working in close conjunction with the other projects, will develop software tools for manipulating, graphically displaying and browsing the high resolution histological and neurochemical brain atlases, starting with the lateral geniculate database, and for distributing simplified images using Internet methodologies. Project 3 will expand a database of retinal cells characterized by morphology, chemistry, physiology and connectivity that provides the model for, and input to the lateral geniculate database. Project 4 will develop a database of monkey visual thalamo- and cortico-cortical connections for integration with the lateral geniculate database, using a newly developed pulvinar database as a model.