Purchase of an EPR Spectrometer

耶鲁大学化学系将从主要研究仪器(MRI)计划获得这一奖项，以获得电子顺磁共振(EPR)光谱仪。新仪器将支持化学、化学工程、分子生物物理和生物化学系的主要用户的研究。将利用这一仪器的一些研究包括：a)光系统II和Mn模型络合物的EPR研究；b)蛋白质二级结构的定点自旋标记研究；c)蛋白质中金属离子结合部位的从头设计；d)活性循环酶和过渡金属吸收的生物无机研究；e)金属氧化物催化剂的表征；f)RNaseP的EPR研究。电子顺磁共振(EPR)光谱仪是用于获得分子的分子和电子结构信息的仪器。它还可以用来获得有关自由基寿命的信息，这些自由基通常是启动肿瘤生长和/或各种化学反应所必需的。这些研究将在许多领域产生影响，特别是生物化学。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Yale University will acquire an Electron Paramagnetic Resonance (EPR) Spectrometer. The new instrument will support the research of major users in the Chemistry, Chemical Engineering, and Molecular Biophysics and Biochemistry Departments. Some of the studies that will exploit this instrument include a) EPR studies of photosystem II and Mn model complexes; b) site directed spin labeling studies of protein secondary structure; c) de novo design of metal ion binding sites in proteins; d) bioinorganic studies of actIV cyclase and transition metal uptake; e) characterization of metal oxide catalysts; and f) EPR studies of RNase P. An electron paramagnetic resonance (EPR) spectrometer is an instrument used to obtain information about the molecular and electronic structure of molecules. It may also be used to obtain information about the lifetimes of free radicals which are often essential for the initiation of tumor growth and/or a variety of chemical reactions. These studies will have an impact in a number of areas, in particular biological chemistry.