MRI/RUI: Acquisition of a 500-MHz Nuclear Magnetic Resonance Spectrometer at Western Washington University

有了这一重大研究仪器(MRI)计划的奖励，西华盛顿大学化学系将获得一台500 MHz核磁共振光谱仪。该设备将使研究人员能够开展以下研究：a)化感作用天然产物的全合成和通过苯酚-环氧化物环化反应制备中环醚；b)新型抗磁性D10金属异吲哚配合物的合成和表征；c)与早发性家族性阿尔茨海默病相关的突变蛋白的结构表征；d)对一些神经退行性疾病中重要的神经类固醇的分子识别研究；e)肌红蛋白环状置换蛋白的结构表征，以了解氧运输蛋白中的折叠功能关系；以及f)新型倍半萜天然产物的结构鉴定。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。这些核磁共振研究的结果将对包括分子生物学和药物化学在内的许多领域产生影响。

With this award from the Major Research Instrumentation (MRI) Program, the Department of Chemistry at Western Washington University will acquire a 500 MHz NMR Spectrometer. This equipment will enable researchers to carry out studies on a) the total synthesis of allelopathic natural products and the preparation of medium ring ethers via phenol-epoxide cyclization reactions; b) synthesis and characterization of novel diamagnetic d10 metal isoindoline complexes; c) structural characterization of mutant proteins implicated in early-onset familial Alzheimer's disease; d) molecular recognition studies of neurosteroids important in a number of neurodegenerative diseases; e) structural characterization of circular permuteins of myoglobin to understand the folding-function relationship in oxygen transport proteins; and f) structural elucidation of novel sesquiterpenoid natural products. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including molecular biology and medicinal chemistry.