Conference: Sixth International Symposium On Cytochome P450 Biodiversity, to be held in Los Angeles, California, August 20-25, 2002

含血红素酶的细胞色素P450单加氧酶超家族含有广泛的单加氧酶活性，这使得它们对几乎所有的生命形式都至关重要。近年来，它们已被证明在人类生长发育中很重要，因为它们参与类固醇生物合成，也在许多药理学领域，因为它们在人类和脊椎动物模型中对药物的激活和/或解毒至关重要。在一个快速和不断扩大的领域，它们已被证明在昆虫和植物的生长发育中很重要，因为它们参与昆虫和植物激素的生物合成途径，在农业领域，因为它们介导除草剂、杀虫剂、杀菌剂和环境污染物的代谢。意识到植物和昆虫P450研究这一领域日益增长的重要性，P450生物多样性国际系列研讨会组委会从更经典的脊椎动物P450研究领域（微粒体和药物氧化系列研讨会）中分支出来，创建了一个独立的、专注的系列，专门研究微生物、植物和昆虫。对于第六届P450生物多样性国际研讨会：微生物、植物和昆虫中P450细胞色素的功能生物化学和分子生物学，组织者努力通过提供平台来介绍模型P450的表达分析方法以及存在于这些非脊椎动物系统中的众多P450的功能分析，继续在本系列的前五次会议中设置的例子。目标是提供一个论坛，讨论该领域的领先研究，通过一个单一的系列讲座48个演讲，穿插预定的海报演讲和充足的时间进行非正式讨论。考虑到这一目标，要求资金帮助支持有竞争力的高级博士预科和博士后学生的差旅费。该系列的国际咨询委员会和科学组织委员会包括来自7个不同国家的代表，其中11个来自美国。会议将于2002年8月20日至25日在加州大学洛杉矶分校的会议中心举行，由加州大学洛杉矶分校生物化学教授Armand J. Fulco主持。Fulco博士的研究重点是通过各种全球合作研究细菌细胞色素p450的特性。预计出席本次会议的人数约为200人，其中来自美国、欧洲和环太平洋地区的代表比例大致相等。

The cytochrome P450 monooxygenase superfamily of heme-containing enzymes contains a widerange of monooxygenase activities that make them critically important to virtually alllife forms. In recent years, they have been shown to be important in human growth anddevelopment because they are involved in steroid biosynthesis and also in manypharmacological areas because they are critical for the activation and/or detoxificationof drugs in human and vertebrate models. In a rapidly and ever-expanding area, they havebeen shown to be important in insect and plant growth and development because of theirinvolvement in biosynthetic pathways for insect and plant hormones and in agriculturalareas because they mediate the metabolism of herbicides, insecticides, fungicides andenvironmental pollutants.Realizing the growing importance of this area of plant and insect P450 research, theorganizing committee for the International Symposium Series on P450 Biodiversity branchedfrom the more classical area of vertebrate P450 research represented in the SymposiumSeries on Microsomes and Drug Oxidations to create an independent and focused seriesdevoted to microorganisms, plants and insects. For the Sixth International Symposium onP450 Biodiversity: Functional Biochemistry & Molecular Biology of P450 Cytochromes inMicroorganisms, Plants and Insects, the organizers have endeavored to continue theexamples set in the five previous meetings in this series by providing platforms for thepresentation of approaches for expression analysis of model P450s as well as functionalanalysis of the numerous P450s existing in these non-vertebrate systems. The goal is toprovide a forum for discussing leading research in the field through a single lectureseries of 48 presentations interspersed with scheduled poster presentations and ample timefor informal discussions. With this goal in mind, funds are requested to help supporttravel expenses for competitively identified advanced predoctoral and postdoctoralstudents.The International Advisory Board and Scientific Organizing Committee for this Seriescontains representatives from seven different countries including eleven from the UnitedStates. The meeting will be held August 20-25, 2002 at the Conference Center on the UCLAcampus and hosted by Armand J. Fulco, Professor of Biochemistry at the University ofCalifornia, Los Angeles (UCLA). Dr. Fulco's research has focused on characterization ofbacterial cytochrome P450s through a variety of world-wide collaborations. It is expectedthat attendance at this meeting will be approximately 200 with participation from theUnited States, Europe and the Pacific Rim in approximately equal proportions.