The Sixth International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems

第六届国际骨免疫学会议：免疫与骨骼系统的相互作用

• 批准号: 9117878
• 负责人: MARK C HOROWITZ
• 金额: $ 1.5万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9117878
• 关键词: Achievement; Area; Bone Marrow; Bone Resorption; Cell Lineage; Cell physiology; Cells; Collaborations; Communication; Crete; Development; Discipline; Disease; Engraftment; Faculty; Goals; Greece; Health; Hematologist; Hematopoietic; Hematopoietic System; Hematopoietic stem cells; Homeostasis; Immune; Immune system; Immunologist; International; Marrow; Mediator of activation protein; Osteoblasts; Osteoclasts; Participant; Research; Research Personnel; Scientist; Senior Scientist; Skeletal system; Structure; bone; bone cell; cytokine; meetings; member; osteoimmunology; public health relevance; skeletal; stem cell niche; success; symposium

 DESCRIPTION (provided by applicant): It is now well accepted that the immune, hematopoietic and skeletal systems have major interactions, which occur for the most part, between the bone and bone marrow. Osteoclasts, the cells that resorb bone, are important cellular mediators of skeletal homeostasis and are derived from hematopoietic precursors that also give rise to immune cells. In addition, numerous cytokines, which were first shown to regulate immune cell function, are now known to regulate bone cells and influence skeletal health. Conversely, cells in the osteoblast lineage and their cytokines are critical for the development of the hematopoietic stem cell niche and the normal development of the hematopoietic and immune cell lineages. Up until recently, scientists involved in immune or bone cell research rarely interacted in a significant way because each discipline developed independently and, for the most part, has remained separate. The fundamental hypothesis of the organizers of this conference is that progress in the field of osteoimmunology, which is the study of the interactions of bone, hematopoietic and immune cells in health and disease, will be delayed unless better communication is established between bone biologists, hematologist and immunologists. The goal of The Sixth International Conference on Osteoimmunology: Interactions of the Immune and Skeletal Systems is to bring together scientists from these fields in a setting that will facilitate, interactions and new collaborations and hasten progress towards understanding the interconnections of the immune, hematopoietic and skeletal system. Our five previous meetings were highly successful and well attended by 100-150 participants from all over the world.

 描述(申请人提供)：目前公认的是，免疫、造血和骨骼系统有主要的相互作用，主要发生在骨骼和骨髓之间。破骨细胞是吸收骨的细胞，是骨骼动态平衡的重要细胞介质，来源于造血祖细胞，造血祖细胞也能产生免疫细胞。此外，最初被证明可调节免疫细胞功能的大量细胞因子，现在已知可调节骨细胞并影响骨骼健康。相反，成骨细胞系中的细胞及其细胞因子对于造血干细胞生态位的发育以及造血系和免疫细胞系的正常发育至关重要。直到最近，参与免疫或骨细胞研究的科学家很少有重大的互动，因为每个学科都是独立发展的，而且在很大程度上保持着独立的状态。这次会议组织者的基本假设是，骨免疫学领域的进展将被推迟，除非骨生物学家、血液学家和免疫学家之间建立更好的沟通。骨免疫学是研究骨、造血和免疫细胞在健康和疾病中的相互作用的学科。第六届国际骨免疫学会议：免疫和骨骼系统的相互作用的目标是将来自这些领域的科学家聚集在一起，以促进相互作用和新的合作，并加速在了解免疫、造血和骨骼系统的相互联系方面取得进展。我们之前的五次会议非常成功，来自世界各地的100-150名与会者出席了会议。