Conference on Frontiers of NMR in Molecular Biology - VIII to be held in Taos, New Mexico at the Taos Covention Center, February 4-10, 2003

该项目支持学生参加将于2003年2月4日至10日在新墨西哥州陶斯举行的分子生物学核磁共振前沿的基石研讨会。本次会议的及时主题反映了NMR不断发展以应对分子生物学和基因组学的新挑战的事实。在基因组规模上提供蛋白质结构的挑战已经产生了新的NMR方法来有效地确定结构。在生物技术应用中具有更多目标的前景催生了筛选小分子和大分子相互作用的新方法。认识到生物功能往往涉及在动态环境中的大分子组的相互作用，导致了监测大分子复合物中的相互作用和运动的新方法。随着新方法和新认识的出现，也带来了更多的挑战。大量的数据和新类型的数据需要创新的分析方法，相互作用的大分子组装意味着与更大的结构一起工作，蛋白质动力学的新数据源需要与机械模型建立新的联系。与更大的系统一起工作所需的新技术进步通常来自固体NMR与溶液NMR方法的结合。计算生物学已经准备好组织不同类型的数据，生成分子模型，并将其转化为预测工具。会议的最终挑战将是激发来自这些不同领域的科学家之间的讨论。会议将强调应对上述挑战的新方法，并为分子生物学家，NMR光谱学家和计算生物学家提供一个讨论论坛。该计划将围绕问题领域组织，并整合对解决方案有不同观点的科学家的谈话。在正式演讲会之间安排的休息时间是模拟参与者之间讨论的理想选择，并促进学生与这些不同领域的领导者之间的联系。如上所述，会议的跨学科性质将扩大其潜在影响。会议还将有一个独特的教育组成部分，支持研究生和博士后的出席。将通过组织结构不那么正式的下午讲习班来促进对该领域更实际方面的讨论。这将增加学生与在该地区工作的知名科学家互动的机会。

This project supports attendance of students at the Keystone Symposium on the Frontiers of Nuclear Magnetic Resonance (NMR) in Molecular Biology, which will be held at Taos, New Mexico from February 4-10, 2003. The timely topic of this conference reflects the fact that NMR has continued to evolve to meet new challenges of molecular biology and genomics. Already the challenge of providing structures of proteins on a genomic scale has produced new NMR approaches to efficient structure determination. The prospect of having more targets to implement in biotechnology applications has spawned new means of screening for small-molecule and macromolecule interactions. The realization that biological function often involves the interplay of groups of macromolecules in a dynamic setting has led to new methods for monitoring interactions and motion in large macromolecular complexes. With new approaches and new realizations come additional challenges. Large volumes of data and new types of data demand innovative approaches to analysis, assemblies of interacting macromolecules means working with ever-larger structures, and new sources of data on protein dynamics require new connections to mechanistic models. New technological advances needed to work with larger systems often come from combining solids NMR with solution NMR approaches. Computational biology is well poised to organize diverse types of data, generate molecular models, and turn them into predictive tools. The ultimate challenge for the meeting will be to stimulate discussion among scientists coming from these diverse fields. The meeting will highlight new approaches to the challenges defined above and provide a forum for discussion among molecular biologists, NMR spectroscopists, and computational biologists. The program will be organized around problem areas and integrate talks by scientists having different perspectives on their solution. Scheduled breaks between formal presentation sessions are ideal for simulating discussion among participants, and promoting contact between students and established leaders in these diverse fields. The interdisciplinary character of the meeting, as described above, will broaden its potential impact. The meeting will also have a distinct educational component by its support for the attendance of graduate students and postdoctoral associates. Discussion of more practical aspects of the field will be promoted by the organization of afternoon workshops having a less formal structure. These will enhance opportunities for interaction of students with established scientist working in the area.