Frontiers of NMR in Biology

描述(由申请人提供)：本提案旨在请求支持将于2009年2月15-20日在新墨西哥州圣达菲举行的题为“核磁共振生物学前沿”的Keystone研讨会，该会议由Mitsuhiko Ikura和Ann E.McDermott组织。在过去的几十年里，核磁共振波谱已经成为结构和分子生物学中不可或缺的工具，最近在基因组学、蛋白质组学和代谢组学方面做出了贡献。如果没有我们继续努力开发新的方法和应用，核磁共振技术的进步是不可能的。本次研讨会将聚焦于核磁共振光谱学的最新技术进展，以及通过核磁共振研究取得的最新生物发现。重点是研究大的生物系统、膜蛋白、折叠和动力学，以及酶反应或蛋白质相互作用的瞬时状态。因此，那些使用核磁共振的人一直在将其应用扩展到更复杂和更具挑战性的系统，并结合其他生物物理工具，如X射线结晶学和电子显微镜。这次研讨会的目的是提供一个论坛，讨论这些和其他生物核磁共振的新趋势。 与公众健康相关：核磁共振(核磁共振)为研究蛋白质、核酸和其他生物分子提供了独特的方法，从而对生命科学、医药和制药行业产生了巨大影响。蛋白质、核酸和其他生物分子要么在疾病病理中直接起作用，要么可以成为治疗或预防疾病的药物的靶标。本次研讨会将聚焦于核磁共振光谱学的最新技术进展，以及通过核磁共振研究取得的最新生物发现。

DESCRIPTION (provided by applicant): This proposal is to request support for a Keystone Symposia meeting entitled "Frontiers of NMR in Biology", organized by Mitsuhiko Ikura and Ann E. McDermott, which will be held in Santa Fe, New Mexico from February 15 - 20, 2009. Over the past several decades Nuclear Magnetic Resonance (NMR) spectroscopy has become an indispensable tool in structural and molecular biology, with most recent contributions to genomics, proteomics and metabolomics. Advances in NMR technology would not be possible without our continued efforts to develop new methodologies and applications. This symposium will focus on the latest technological advances in NMR spectroscopy as well as recent biological discoveries made through NMR studies. Emphasis will be placed on the investigation of large biological systems, membrane proteins, folding and dynamics, and transient states of enzymatic reactions or protein interactions. As such, those using NMR have been extending its application to more complex and challenging systems in combination with other biophysical tools such as X-ray crystallography and electron microscopy. The purpose of this symposium is to provide a forum for discussion on these and other new trends in biological NMR. PUBLIC HEALTH RELEVANCE: Nuclear Magnetic Resonance (NMR) has had an enormous impact on life science, medicine and the pharmaceutical industry by providing unique methods for investigating proteins, nucleic acids and other biological molecules that either have direct roles in disease pathology or that can be targeted by drugs for disease treatment or prevention. This symposium will focus on the latest technological advances in NMR spectroscopy as well as recent biological discoveries made through NMR studies.