SGER: Biosensing in the Gas Phase: A New Approach Based on Imprinted Nanoparticles of a Linear Polymer

0229026Tepper本项目的目标是开发一种新型的气相生物传感器，能够完全在气相中实时检测化学和生物战剂。最近的研究表明，生物病原体释放的挥发性化学代谢物可能被用作独特的气相特征。因此，挥发性化学物质将被直接检测，而生物物种，如细菌，将通过其挥发性代谢产物被检测。PI将开发具有针对特定生物病原体的挥发性化学代谢物的合成受体位置的纳米颗粒。印迹颗粒将与微型制造的换能器对接，所产生的生物芯片将在暴露于包括代谢物在内的各种蒸汽的情况下进行测试。这项技术有可能减少或消除当前空气采样和分析技术的昂贵、劳动密集型和耗时的实践。如果成功，便携式手持式气相生物传感器可以部署在各种高危地点，为生物和化学制剂提供实时监测。

0229026TepperThe objective of this project is to develop a new kind of gas-phase biosensor to simultaneously detect chemical and biological warfare agents entirely in the gas phase and in real time. Recent studies have demonstrated that biological pathogens emit volatile chemical metabolites that potentially can be utilized as a unique gas-phase signature. Therefore, the volatile chemical agents will be detected directly while the biological species, such as bacteria, will be detected through their volatile metabolites. The PIs will develop nanoparticles possessing synthetic receptor sites targeted to the volatile chemical metabolites of particular biological pathogens. The imprinted particles will be interfaced with a microfabricated transducer and the resulting biochip will be tested under exposure to a variety of vapors including the metabolites. This technology has the potential to reduce or eliminate the costly, labor intensive and time consuming practice of current air sampling and analysis techniques. If successful, a portable, hand-held, gas phase biosensor could be deployed at various high-risk locations to provide real-time monitoring for biological and chemical agents.