Redox Active Dendrimers and Molecular Capsules

有了这项更新建议，有机和高分子化学项目支持了迈阿密大学化学系Angel E.Kaifer教授正在进行的工作。卡弗教授的工作考察了几个大分子和超分子体系的电化学。PI将合成和表征氧化还原活性树枝状大分子，研究这些树枝状大分子中客体残基与自由扩散的宿主分子之间的新的主客体结合作用，并设计和开发能够在氧化还原控制下形成分子胶囊的新系统。PI提出了一个清晰的计划，旨在更好地了解控制电子转移到树枝状大分子焦点上的氧化还原基团的热力学和动力学的因素。这些都是重要的研究，因为与生物无机群落不同，卡弗的工作旨在利用氧化还原基团周围的二级结构来控制氧化还原性质。这正是发生在蛋白质中的事情。这项工作的成功将凯弗教授引向了一个新的方向，即使用较小的宿主分子组装树突。在未来，这将提供一种组装更复杂的超分子的方法，这些超分子甚至是更好的蛋白质类似物。有了这一奖项，迈阿密大学化学系的有机和高分子化学项目支持了安吉尔·E·卡弗教授在迈阿密大学化学系的研究活动。卡弗教授的工作意义重大，因为他的研究可能会导致新型电化学传感器和智能材料的发展。此外，它还可以提供对生物电子转移反应的洞察。这项工作将由一群不同的研究生和博士后助理进行，他们将接受合成、色谱、光谱和电化学技术方面的培训。

With this renewal proposal the Organic and Macromolecular Chemistry Program supports the ongoing work of Professor Angel E. Kaifer in the Department of Chemistry at the University of Miami. Professor Kaifer's work examines the electrochemistry of several macromolecular and supramolecular systems. The PI will synthesize and characterize redox active dendrimers, investigate new host-guest binding interactions between guest residues in these dendrimers and freely diffusing host molecules, and design and develop novel systems capable of forming molecular capsules under redox control. The PI has presented a clearly articulated plan intended to better understand the factors that control the thermodynamics and kinetics of electron transfer to redox groups appended to the focal point of dendrimers. These are important studies, because unlike the bioinorganic community, Kaifer's work is intended to use the secondary structure around the redox group to control redox properties. This is precisely what happens in proteins. The success of this work is leading Professor Kaifer in a new direction that involves the assembly of dendrons using smaller host molecules. In the future, this should provide a means to assemble more complex supermolecules that are even better protein analogs.With this Award, the Organic and Macromolecular Chemistry Program of the Division of Chemistry supports the research activities of Professor Angel E. Kaifer in the Department of Chemistry at the University of Miami. Professor Kaifer's work is significant since his studies may lead to the development of novel electrochemical sensors and intelligent materials. Also, it may provide insight into biological electron transfer reactions. The work will be carried out by a diverse group of graduate students and postdoctoral associates who will be trained in synthetic, chromatographic, spectroscopic and electrochemical techniques.