Telling Glycosyl Donors Where to Go

本研究的重点涉及使用互惠供体受体选择性（RDAS）进行寡糖的生产。使用该方法，可以实现差异化的双糖苷化。减少对保护基的依赖性和将供体引导至特定OH基团的能力使该方法具有在糖苷化中进行立体和区域控制的巨大潜力。该方法可能会对目前用于制备支链寡糖的合成方法产生重大影响。有了这个奖项，有机和大分子化学计划将支持Bert O博士的研究。Fraser-Reid，天然产品和糖技术研究所，Inc。Fraser-Reid博士的工作重点是利用供体/受体匹配的概念合成寡糖，其中单取代二醇的结构指导分子与第二种糖苷化剂的反应，以提供许多可能的寡糖之一。这项工作在合成碳水化合物化学领域具有更广泛的影响潜力。

The focus of this research involves the use of Reciprocal Donor Acceptor Selectivity (RDAS) to carry out the production of oligosaccharides. Using the method, differential double-glycosidations can be achieved. The ability to lessen dependence on protecting groups and the ability of guiding a donor to a specific OH group give the method great potential for stereo-and regio-control in glycosidations. The method could have a great impact on the current synthetic methodologies used for the preparation of branched-chain oligosaccharidesWith this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Bert O. Fraser-Reid at the Natural Products and Glycotechnology Research Institute, Inc. Dr. Fraser-Reid will focus his work on the synthesis of oligosaccahrides using the concept of donor/acceptor matching wherein the structure of a monosubstituted diol guides the reaction of the molecule with a second glycosidating agent to afford one of many possible oligosaccharides. The work has great potential for broader impact in the field of synthetic carbohydrate chemistry.