Switched-Angle NMR of Oriented Membrane Proteins

MPS杰出国际博士后奖学金计划(MPS-DRF)使美国科学家能够在国外开展研究。这使得获奖者有机会从非美国机构的专业知识、设施和互动中受益于合作研究。该奖项将支持Megan M.Spence博士与Beat H.Meier教授及其团队在瑞士苏黎世联邦理工学院(Swiss Federal Institute Of Technology Zurich)的毛皮物理化学实验室与BEAT H.Meier教授合作的24个月研究奖学金。拟议的研究将使用固态核磁共振波谱(NMR)来研究膜相关蛋白质的结构。切换角度旋转是一种固体核磁共振技术，作为原理实验的证明，它将被用来确定双列关联多肽的原型结构。比特·迈耶教授是固态核磁共振领域的权威人士。他的实验室已经开发出在纺纱技术下使用双极管的程序。这将有助于斯宾塞博士有效地开展拟议的工作。

The MPS Distinguished International Postdoctoral Fellowship Program (MPS-DRF) enables U.S. scientists to conduct research abroad. This allows the awardees the opportunity for collaborative research benefiting from expertise, facilities and interactions in a non-U.S. institution.This award will support a 24-month research fellowship for Dr. Megan M. Spence to work with Prof. Dr. Beat H. Meier and his group at the Laboratorium fur Physikalische Chemie, Eidgenossische Technische Hochschule Zurich (Swiss Federal Institute of Technology Zurich).The proposed study will investigate the structure of membrane associated proteins using solid-state nuclear magnetic resonance spectroscopy (NMR). Switched-angle spinning, a solid-state NMR technique, will be employed to determine the structure of a prototype bicelle-associated polypeptide as a proof of principle experiment. Prof. Dr. Beat Meyer is a leading authority in the field of solid-state NMR. His laboratory has developed procedures to use bicelles under spinning techniques. This will assist Dr. Spencer to effectively carry out the proposed work.