The UK Dynamic Nuclear Polarisation Magic Angle Spinning NMR Facility
英国动态核极化魔角旋转核磁共振设备
基本信息
- 批准号:EP/W021528/1
- 负责人:
- 金额:$ 236.67万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Research Grant
- 财政年份:2022
- 资助国家:英国
- 起止时间:2022 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Solid-state Nuclear Magnetic Resonance (NMR) spectroscopy is a key technique for understanding atomic-scale level structures and dynamics in the biological, chemical, physical and material sciences. However, despite its unique versatility and high chemical environments information content, NMR suffers from low sensitivity, due to the weak nuclear polarisation, and requires long experiment times, especially for dilute species such as those in low concentrations or intrinsically insensitive with small magnetic moments. Dynamic Nuclear Polarisation (DNP) is an emerging technology that can enhance the NMR signal intensities by up to three orders of magnitude and involves polarisation transfer from the much larger polarisation of unpaired electrons in radicals or metal ions, either implanted or inherently present in the samples, to the nearby nuclei followed by NMR detection. The advent of commercial spectrometers for DNP Magic Angle Spinning (MAS) NMR since 2008 has redirected research efforts away from the initial instrumentation development to more application-driven research. The pathway to success relies heavily on obtaining high signal enhancements by achieving optimal sample formulation which involves an appropriate choice of the unpaired electrons and of a suitable matrix to embed them in the sample of interest. Many pioneering applications have since emerged, demonstrating the unique potential of this novel spectroscopy method for addressing a wide variety of different research challenges ranging from energy storage materials, catalysis, drug delivery to biological molecules with tremendous potential for wider utilisation in the future. The importance of DNP MAS NMR has been recognised in a review of the UK NMR landscape commissioned and published by the EPSRC as an NMR roadmap in 2013 (and updated in 2017) that stressed the urgent need for significant capital investment in this technology. Key recommendations were the immediate provision of the first commercial DNP MAS NMR system in the UK, that led to the funding of the Nottingham DNP MAS NMR Facility operating a 14.1 T instrument (EP/L0222524/1) in 2015, and at least two additional systems across the UK in the medium term, that triggered the submission of a business case to the EPSRC Strategic Equipment Process for a 9.4 T system by the University of Manchester in partnership with the University of Liverpool in 2020. The recommendations of the NMR roadmap were recently corroborated by a Statement of Community Need submitted in 2019 by the University of Cambridge, representing the external user group of the Nottingham Facility, which was prioritised by the EPSRC National Research Facility panel. In response to these decade-long activities, EPSRC invited the community to submit a full proposal to the Strategic Equipment Process for the provision of DNP MAS NMR spectroscopy to serve the UK science community. Here, we propose to establish a distributed DNP MAS NMR Facility located over the three host institutions by combining the full operation of the 14.1 T Nottingham DNP MAS NMR Facility with a fraction of experimental time of the 9.4 T system at the University of Cambridge and a new 9.4 T instrument at the University of Manchester, augmented by additional capabilities for fast MAS, that, taken together, will provide the UK community with both regular access to instrumentation and world-class expertise. We will deliver on this major transformative investment in DNP MAS NMR by being able to benefit EPSRC Prosperity Outcomes, impact Research Themes and cover many Research Areas. Critical to the success and sustainability of this distributed Facility is the support of two Facility Managers with funding for operating costs coupled to one management structure with a single-entry point application procedure, strong community support and wide dissemination and outreach strategies engaging (DNP) NMR experts with the broader UK research communities.
固体核磁共振波谱是了解生物、化学、物理和材料科学中原子级结构和动力学的关键技术。然而,尽管核磁共振具有独特的多功能性和高化学环境信息含量,但由于核极化较弱,因此其灵敏度较低,并且需要较长的实验时间,特别是对于低浓度或本质不敏感的小磁矩物种。动态核极化(DNP)是一种新兴技术,它可以将核磁共振信号强度提高高达三个数量级,涉及从注入或固有存在于样品中的自由基或金属离子中较大极化的未配对电子转移到附近的原子核,然后进行核磁共振检测。自2008年以来,用于DNP魔角旋转(MAS)核磁共振的商用光谱仪的出现将研究努力从最初的仪器开发转向更多应用驱动的研究。成功的途径在很大程度上依赖于通过实现最佳的样品配方来获得高信号增强,这涉及到适当地选择未配对的电子和合适的基质将它们嵌入到感兴趣的样品中。自那以后,出现了许多开创性的应用,展示了这种新颖的光谱方法在解决从储能材料、催化、药物输送到生物分子等各种不同研究挑战方面的独特潜力,在未来具有巨大的应用潜力。EPSRC委托进行的一份对英国核磁共振图景的审查认识到了DNP MAS核磁共振的重要性,该报告是2013年(并于2017年更新)的核磁共振路线图,强调迫切需要对这项技术进行重大资本投资。主要建议是立即在英国提供第一个商用DNP MAS核磁共振系统,从而在2015年为诺丁汉DNP MAS核磁共振设施提供资金,运营一台14.1T仪器(EP/L0222524/1),并在中期内在英国各地至少额外提供两个系统,促使曼彻斯特大学与利物浦大学合作,于2020年向EPSRC战略设备流程提交9.4T系统的商业案例。核磁共振路线图的建议最近得到了剑桥大学2019年提交的一份社区需求声明的证实,该声明代表诺丁汉设施的外部用户群体,EPSRC国家研究设施小组将其列为优先事项。作为对这些长达十年的活动的回应,EPSRC邀请社区向战略装备进程提交一份完整的建议,以提供DNP MAS核磁共振光谱分析,以服务于英国科学界。在这里,我们建议建立一个分布在三个主办机构的DNP MAS核磁共振设施,将14.1T诺丁汉DNP MAS核磁共振设施的全面运行与剑桥大学9.4T系统的一小部分实验时间和曼彻斯特大学的一个新的9.4T仪器相结合,并增加快速MAS的能力,两者结合在一起,将为英国社区提供定期访问仪器和世界级专业知识的机会。我们将通过能够惠及EPSRC繁荣成果、影响研究主题和涵盖许多研究领域来实现DNP MAS核磁共振的这一重大变革性投资。这一分布式设施的成功和可持续发展的关键是两个设施经理的支持,他们为运营成本提供资金,并与一个管理结构相结合,采用单一入口点申请程序、强大的社区支持以及吸引(DNP)核磁共振专家与更广泛的英国研究社区的广泛传播和外联战略。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Walter Kockenberger其他文献
Walter Kockenberger的其他文献
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{{ truncateString('Walter Kockenberger', 18)}}的其他基金
Maximising the sharing of the Nottingham DNP MAS NMR Facility
最大限度地共享诺丁汉 DNP MAS NMR 设施
- 批准号:
EP/R042853/1 - 财政年份:2018
- 资助金额:
$ 236.67万 - 项目类别:
Research Grant
Dynamic Nuclear Polarisation And Non-Equilibrium Physics
动态核极化和非平衡物理
- 批准号:
EP/N03404X/1 - 财政年份:2016
- 资助金额:
$ 236.67万 - 项目类别:
Research Grant
High-field Dynamic Nuclear Polarization Magic Angle Spinning NMR for Chemistry, Physics, Materials, Pharmaceuticals and Biomolecular Science
高场动态核极化魔角旋转 NMR 适用于化学、物理、材料、制药和生物分子科学
- 批准号:
EP/L022524/1 - 财政年份:2014
- 资助金额:
$ 236.67万 - 项目类别:
Research Grant
Combining cryo-DNP and rapid temperature jumps at high magnetic field for a dramatic increase of sensitivity in liquid state NMR spectroscopy
将冷冻 DNP 与高磁场下的快速温度跃变相结合,可显着提高液态 NMR 光谱的灵敏度
- 批准号:
EP/I036702/1 - 财政年份:2012
- 资助金额:
$ 236.67万 - 项目类别:
Research Grant
Spin dynamics and optimisation of dynamic nuclear polarisation at cryogenic temperatures
低温下动态核极化的自旋动力学和优化
- 批准号:
EP/I027254/1 - 财政年份:2011
- 资助金额:
$ 236.67万 - 项目类别:
Research Grant
Ultrafast nuclear magnetic resonance spectroscopy using parallel detection and DNP enhancement for studies of molecular dynamics
使用并行检测和 DNP 增强的超快核磁共振波谱用于分子动力学研究
- 批准号:
BB/F004885/1 - 财政年份:2008
- 资助金额:
$ 236.67万 - 项目类别:
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