New Ligands and Catalysts for Asymmetric Synthesis

这项研究的重点涉及手性双环内酰胺及其相关衍生物衍生的亲核和Lewis酸性金属络合物的合成应用。这些配合物将在金属介导的官能化的烯丙基与醛的加成反应、铜酸盐介导的共轭加成反应和[3，3]Sigmatroic重排反应中得到评价。通过这一奖项，有机和高分子化学项目支持罗切斯特大学化学系罗伯特·K·博克曼博士的研究。博克曼教授将把研究重点放在开发催化不对称合成方法学上。这项工作有可能对制药行业产生更广泛的影响，该项目将培养研究生成为有机合成方面的专家。

The focus of this research involves the synthetic use of nucleophilic and Lewis acid metal complexes derived from chiral bicyclic lactams and related derivatives. The complexes will be evaluated in the metal-mediated additions of functionalized allyl moieties to aldehydes, cuprate mediated conjugate additions and [3,3] sigmatropic rearrangements. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Robert K. Boeckman in the Department of Chemistry at the University of Rochester. Professor Boeckman will focus his research efforts on developing methodology for catalytic asymmetric synthesis. There is potential for broader impact of the work for the pharmaceutical industry and the project will train graduate students to become experts in organic synthesis.