CAREER: A Novel Liquid Crystal System for Capillary Electrophoresis

肯特州立大学的Lisa A. Holland教授受到分析和表面化学CAREER项目的资助，研究磷脂单胞体作为电动毛细管色谱的固定化分配介质。这项工作包括详细表征双胞介质作为温度、混合胶束比、浓度和组成的函数。然后优化该材料的筛选能力，用于多肽、蛋白质和DNA的分离。bicelle溶液结合基于生物素-亲和素化学的受体系统的能力将被利用。这项工作的教育部分侧重于利用远程学习来启动哈斯克尔印第安民族大学的分离研究项目。兴趣在于筛选传统部落药物的受体亲和力。

Professor Lisa A. Holland of Kent State University is funded by the Analytical and Surface Chemistry CAREER program to study phospholipid bicelles as immobilized partitioning media for electrokinetic capillary chromotography. The work involves the characterization of the bicelle media in detail as a function of temperature, mixed micelle ratios, concentration and composition. Then the sieving capabilities of this material will be optimized for separation of polypeptides, proteins and DNA. The ability of bicelle solutions to incorporate receptor systems based on biotin-avidin chemistry will be utilized. The educational component of this work focuses on the use of distance learning to initiate a research program in separations at Haskell Indian Nations University. The interest is in screening traditional tribal medicines for receptor affinity.