Stem cell-based interface tissue engineering

骨关节炎（OA）会导致极度疼痛、残疾、生活质量和整体生产力下降。它是国际上社会和经济影响最大的肌肉骨骼疾病，预计到2030年将有9.3%的成年人口患有OA。组织工程产品能够修复韧带-软骨-骨组织界面将有显著的好处。它将改善患者的活动和生活质量，并显著降低与oa相关的医疗保健费用。该计划将为澳大利亚科学界和工业界培养12名干细胞生物学和组织工程新兴领域的新一代研究人员。

Osteoarthritis (OA) causes extreme pain, disability, and reduced quality of life and overall productivity. It is the musculoskeletal disorder with the greatest social and economic implications internationally, with 9.3% of the adult population projected to suffer from OA by 2030. A tissue engineered product capable of functional repair of ligament-cartilage-bone tissue interfaces will have significant benefits. It will improve patient activity and quality of life, and significantly reduce OA-associated health care costs. This proposal will train a total of 12 new generation researchers in the emergent fields of stem cell biology and tissue engineering, having important benefits for the Australian scientific and industrial communities.