Supramolecular and Electrochemical Studies of Organometallics

布朗大学的德怀特·斯韦加特得到了无机、生物无机和有机化学项目的支持，研究由金属和有机金属分子自组装产生的超分子配位网络的合成和研究。 该网络将基于过渡金属如锰、铁和钌的π键合醌络合物。 这些网络具有电化学活性，具有广泛的可访问设计和架构。 最初的目标包括合成包含大孔、纳米管和叉指π-π网络的材料。 该项目还包括醌甲基化物的稳定化和研究，醌甲基化物是在黑色素和木质素的生物合成、抗肿瘤药物的作用以及BHT等食品添加剂的代谢氧化中具有巨大重要性的高活性分子。 醌甲基化物的稳定化将通过与过渡金属的π配位来尝试。 所提出的醌类配位网络和稳定的醌甲基化物在磁性、传感、催化、解毒和药物传递等方面具有潜在的应用价值。 从事该项目的学生将获得合成和光谱方法，X射线晶体学以及电化学技术在基础和技术上重要的化学过程中的应用方面的广泛专业知识。

Dwight Sweigart, Brown University, is supported by the Inorganic, Bioinorganic and Organometallic Chemistry Program for the synthesis and study of supramolecular coordination networks generated by the self-assembly of metallic and organometallic molecules. The networks will be based on pi-bonded quinone complexes of transition metals such as manganese, iron, and ruthenium. These networks are electrochemically active and feature a wide range of accessible designs and architectures. Initial goals include the synthesis of materials that incorporate large pores, nanotubes, and interdigitated pi-pi networks. This project also includes the stabilization and study of quinone methides, which are highly reactive molecules of enormous importance in the biosynthesis of melanin and lignin, the action of anti-tumor drugs, and the metabolic oxidation of food additives such as BHT. The stabilization of quinone methides will be attempted by pi-coordination to transition metals. The proposed quinonoid coordination networks and the stabilized quinone methides have potential applications in magnetics, sensing, catalysis, detoxification and drug delivery protocols. Students working on this project will gain broadly-based expertise in synthetic and spectroscopic methods, X-ray crystallography and in the application of electrochemical techniques to fundamental and technologically important chemical processes.