Incorporating High-Field NMR Spectroscopy Throughout the Undergraduate Chemistry Curriculum

许多本科生对科学的吸引力在于它的实验性质，他们从实践中学习。在化学及相关领域，核磁共振波谱可以说是最成熟和最广泛应用的结构确定和动态测量的实验技术之一。近年来，核磁共振光谱学对化学教育产生了巨大的影响，因为高场光谱仪通过NSF的支持越来越多地提供给本科生机构。为了加强整个化学课程，吸引和留住更多的理科学生，并为这些学生的研究生工作和科学就业做好更好的准备，德保罗大学在其四年制课程中引入了动手操作的高场FT-核磁共振光谱学。该项目仿照NSF资助的类似项目，这些项目在将核磁共振波谱作为教学工具(Davis-UE9751056，Ball-DUE9950413，Liotta-DUE0126678)方面发挥了极其有效的作用。课程的所有级别的学生通过实验亲身体验核磁共振光谱学，这些实验已经改编自文献(主要来自J.Chem)。(Ed.)或在德保罗发展起来的。在普通化学中，学生使用质子去耦合碳核磁共振来确定简单同分异构烃的结构，并观察电负性原子对化学位移的影响。在有机化学中，质子核磁共振和多维技术被用来确定未知和反应产物的结构，特别是新型单体和共聚物的结构。物理化学、仪器分析、中间无机和生物化学专业的研究生和高年级学生使用核磁共振波谱测定(二氢和二氢有机金属络合物)的结构，并评估动态过程(平衡、酮烯醇互变、氢键、酵母代谢)。通过逐步更复杂的实验，学生学习欣赏核磁共振光谱学的全部功能，同时也发展他们解决问题和批判性思维的技能，并增强他们对化学的整体理解和每个分支学科的相关性。

Chemistry (12) The attraction for many undergraduate students to science is the experimental nature of it; they learn by doing. In chemistry and related fields, NMR spectroscopy is arguably one of the most well-developed and broadly applicable experimental techniques for structure determination and dynamic measurements. In recent years, NMR spectroscopy has had an enormous impact on chemistry education as high field spectrometers become more available to undergraduate institutions through NSF support. In order to strengthen the overall chemistry curriculum, attract and retain more science students, and better prepare those students for graduate work and employment in the sciences, DePaul University is incorporating hands-on high field FT-NMR spectroscopy throughout its four-year program. This project is modeled after similar NSF-funded programs that have been extremely effective elsewhere at exploiting the full power of NMR spectroscopy as a teaching tool (Davis-UE9751056, Ball-DUE9950413, Liotta-DUE0126678). Students at all levels of the curriculum experience NMR spectroscopy first-hand, through experiments that have been adapted from the literature (primarily from J. Chem. Ed.) or developed at DePaul. In general chemistry, students use proton-decoupled carbon NMR to determine the structure of simple isomeric hydrocarbons and observe the effect of electronegative atoms on chemical shift. In organic chemistry, proton NMR and multidimensional techniques are used to determine the structure of unknowns, and reaction products, especially novel monomers and copolymers. Research students and upper level students in physical chemistry, instrumental analysis, intermediate inorganic, and biochemistry use NMR spectroscopy for both structure determination (of dihydride and dihydrogen organometallic complexes) and to evaluate dynamic processes (equilibrium, keto-enol tautomerism, hydrogen bonding, yeast metabolism). Through progressively more sophisticated experiments, students learn to appreciate the full power of NMR spectroscopy while also developing their problem solving and critical thinking skills, and enhancing their overall understanding of chemistry and the relatedness of each subdiscipline.