Advanced conjugated oligomers and polymers with switchable optical properties, supramolecular characteristics, and sensitivity to biomolecules

申请人他以前的研究表明，利用荧光染料的可逆化学反应来定量醇类、生物胺、硫醇和硫醇是可能的。在研究中的化学反应性染料中，芪衍生物是共轭聚合物材料的模型，与有机发光二极管、晶体管、光电二极管、太阳能电池和（生物）化学传感器的制备高度相关。该项目的第一个重点是合成在400 - 700 nm左右具有吸收和荧光的先进共轭聚合物。它们具有连接到聚合物上的化学反应性基团，这不仅有利于增强光化学稳定性，而且还允许切换材料的光学性质。这与定制和微调有机发光二极管的性能有关。第二个重点是制备具有多个反应性基团的低聚物，这些基团能够形成共价超分子复合物。这些自组织三维结构的物理性质将受到光刺激或温度变化的影响。第三个重点是使用共轭材料制备功能性发光二极管，作为细胞中的纳米颗粒，或作为光纤和微电子器件上的传感器层。化学反应性共轭低聚物和聚合物将用于检测生物分子，因为共轭结构对它们的能量迁移中的非常小的扰动非常敏感，这导致对分析物分子的灵敏度放大。

The applicant¿s previous research has shown that it is possible to use reversible chemical reactions of fluorescent dyes to quantify alcohols, biogenic amines, thiols, and saccharides. Among the chemically-reactive dyes under investigation were stilbene derivatives which are models for conjugated polymers ¿ materials, that are highly relevant for the preparation of organic light emitting diodes, transistors, photodiodes, solar cells, and (bio)chemical sensors. The first focus of this project is on the synthesis of advanced conjugated polymers with absorbance and fluorescence at around 400 ¿ 700 nm. They possess chemically-reactive groups attached to the polymer which are not only beneficial in enhancing photochemical stability but furthermore allow to switch the optical properties of the materials. This is of relevance for tailoring and fine-tuning the performance of organic light emitting diodes. The second focus is on the preparation of oligomers with multiple reactive groups that are capable of forming covalent supramolecular complexes. The physical properties of these self-organising three-dimensional structures will be affected by light stimulation or changing temperatures. The third focus is to use the conjugated materials for the preparation of functional light emitting diodes, as nanoparticles in cells, or as sensor layers on optical fibres and miniaturised devices. Chemically-reactive conjugated oligomers and polymers will be used to detect biomolecules because conjugated structures are extraordinarily sensitive to very minor perturbations in their energy migration which results in amplified sensitivity towards analyte molecules.