SGER: Feasibility of High Gradient Magnetic Implants for Targeted Drug Delivery

建议标题：SGER：高梯度磁性植入物用于靶向药物输送的可行性建议编号：CTS-0314157主要调查者：James RitterInstitution：南卡罗来纳大学拟议研究的目标是将磁性颗粒整合到药物载体中，并利用磁场将药物引导到特定位置。该项目将基于PI在高梯度磁分离(HGMS)概念方面的专业知识，以确定使用磁性增强型靶向药物输送作为一种可行的治疗工具的可行性。虽然已经发展了描述流动气流中磁流体液滴保留的一般现象学理论，但还没有理论工作来探索使用磁场进行靶向药物输送的局限性。第一个目标是从理论上确定使用铁磁丝在含药纳米颗粒通过动脉时局部增强其作用力的可行性和局限性。我们将探索各种条件下的模拟。感兴趣的参数包括钢丝磁性、钢丝直径、流体速度和血液粘度。就更广泛的影响而言，这一概念有可能针对特定地点的药物，从而减少总剂量和潜在的副作用。还将开展研究生和本科生的传统辅导。该项目的创新之处在于确定了使用电生磁场来指导药物输送的可行性。如果成功，该项目可能会带来一种新的技术，可以有效地提供更高浓度的药物，用于治疗癌症、血栓和其他疾病

AbstractProposal Title: SGER: Feasibility of High Gradient Magnetic Implants for Targeted Drug DeliveryProposal Number: CTS-0314157Principal Investigator: James RitterInstitution: University of South CarolinaThe objective of the proposed research is to incorporate magnetic particles into drug carriers and direct the drug to a specific site using a magnetic field. This project will build on the PI's expertise in high gradient magnetic separation (HGMS) concepts to determine the feasibility of a using magnetically enhanced targeted drug delivery as a viable therapeutic tool. Although a general phenomenological theory to describe the retention of a ferrofluid drop in a flowing stream has been developed, no theoretical work has been doen to explore the limitations of the use of magnetic fields for targeted drug delivery. The first objective is to determine theoretically the feasibility and limitations of using ferromagnetic wires to locally enhance the force on a drug-containing nanoparticle as it travels through the artery. Simulations over a wide range of conditions will be explored. Parameters of interest include wire magnetic properties, wire diameter, fluid velocity, and blood viscosity. In terms of the broader impacts, this concept has the potential to target drugs to specific locations, thus reducing overall dosage and reducing potential side effects. The traditional mentoring of graduate and undergraduate students will also be carried out. The novelty of this project is to determine the feasibility of using electrically-generated magnetic fields for directing drug delivery. If successful, the project may lead to a new technique for effectively delivering increased con.centrations of drugs for use in the treatment of cancer, blood clots, and other medical conditions