New Directions in Selectivity via Palladium and Indium Mediated Methodology

本研究的重点有三个方面。首先，采用钯催化的异构化反应和动力学烯丙基取代反应制备恶唑类化合物和邻二胺。第二，In催化原子转移环化方法的研究。第三，醛和亚胺的间接烯丙化反应，利用钯催化生成活性铟配合物。通过这一奖项，有机和高分子化学计划支持北达科他州立大学化学系格雷戈里·R·库克博士的研究。库克博士的工作重点将是开发钯催化合成氨基醇和二胺的合成方法，以及使用铟催化开发环保的有机合成工艺。该项目可能会对制药业和整个绿色化学产生更广泛的影响。该项目也为研究生的培训提供了一个极好的场所。

The foci of this research are three fold. First, Pd-catalyzed isomerization and kinetic allylic substitution will be used to prepare oxazolines and vicinal diamines. Second, In-catalyzed atom transfer cyclization methodology will be studied. Third, In-mediated allylation of aldehydes and imines, utilizing Pd-catalysis to generate reactive indium complexes, will be developed.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Gregory R. Cook in the Department of Chemistry at North Dakota State University. Dr. Cook will focus his work on developing synthetic methodology for the palladium-catalyzed synthesis of aminoalcohols and diamines and on the use of indium catalysis to develop eco-friendly processes for organic synthesis. The project could have broader impact for the pharmaceutical industry and for green chemistry in general. The project also presents an excellent venue for the training of graduate students.