New Approaches to Catalyst Screening and Development

本研究的重点是开发用于有机催化剂快速评价的原位酶筛选方法。该项目将努力更好地建立关于副产品和产品的技术广度，它将确定更高吞吐量分析的可能性，并将调查获得关于催化剂对映体选择性和相对速率的实时信息的可能性。通过这一奖项，有机和高分子化学项目支持内布拉斯加州-林肯大学化学系的David B.Berkowitz博士的研究。伯科维茨教授将专注于开发酶在合成实验室中的新应用；即作为灵敏、实时的手性传感器。在需要信息丰富、快速催化剂筛选的学术界和工业界，这项工作都有可能产生更广泛的影响。此外，该项目还为研究生的跨学科培训提供了一个极好的舞台。

The focus of this research involves the development of in situ enzymatic screening for the rapid evaluation of organic catalysts. The project will strive to better establish the breadth of the technique with respect to both byproduct and product, it will determine the possibility for much higher throughput assays, and it will investigate the possibility of obtaining real time information about catalyst enantioselectivity, as well as relative rate. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. David B. Berkowitz in the Department of Chemistry at the University Nebraska-Lincoln. Professor Berkowitz will focus on developing a new application of enzymes in the synthetic laboratory; namely as sensitive, real time, chiral sensors. There is potential for broader impact of the work in both academia and industry where information rich, rapid catalyst screens are in demand. Also, the project presents an excellent arena for the interdisciplinary training of graduate students.