SGER: A New Interfacial Free-Radical Polymerization Approach for Direct Hollow Capsule Encapsulation

摘要：卡洛斯Co机构：建议编号：0324303智力优点：这个SGER项目是探索性研究的界面自由基聚合方法的直接封装基板在空心胶囊与纳米厚的聚合物壳。 该方法依赖于马来酸酯和乙烯基醚单体的界面交替共聚。 通过选择这两种单体类型的疏水性和亲水性组合，其单独地不均聚，聚合被限制为仅在油/水界面处发生。 这种封装技术背后的原理和方法，如果得到证实，将允许通过可扩展的，廉价的工艺直接封装许多基板，在操纵壳厚度，渗透性和表面化学方面具有高度的灵活性和控制性。广泛的影响：该方法潜在地结合了现有中空包封技术的最佳特征，可以在许多药物、染料、细胞、酶、此外，界面自由基交替共聚的一般原理具有许多潜在的应用，其延伸到中空胶囊封装之外并进入许多已建立的纳米技术，其中界面的优势突出了这种聚合技术的重要性。 该项目还将在界面现象和自由基聚合的原理方面对本科生和研究生进行教育和培训。

ABSTRACTPI: Carlos Co Institution: University of CincinnatiProposal Number: 0324303Intellectual Merit:This SGER project is exploratory research on an interfacial free-radical polymerization approach for the direct encapsulation of substrates in hollow capsules with nanometer thick polymer shells. This approach relies on the interfacial alternating copolymerization of maleate and vinyl ether monomers. By choosing hydrophobic and hydrophilic combinations of these two monomer types, which individually do not homopolymerize, the polymeriztion is constrained to occur only at oil/water interfaces. The principles and methodology behind this encapsulation technique, if proven, will allow for the direct encapsulation of many substrates through a scalabale, inexpensive process presenting a high degree of flexibility and control in manipulating the shell thickness, permeability, and surface chemistry.Broad Impact:This process, which potentially combines the best features of existing hollow encapsulation technologies, could have widespread and immediate applications in the encapsulation and controlled release of many drugs, dyes, cells, enzymes, transfection vectors, etc. In addition, the general principle of interfacial free-radical alternating copolymerziation has many potential applications extending beyond hollow-capsule encapsulation and into many established nanotechnologies where the preponderance of interfaces accentuates the significance of this polymerization technique. The project will also serve to educate and train undergraduate and graduate students in the principles of interfacial phenomena and radical polymerizations.