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Interfacial Control and Manipulation for the Development of New Ophthalmic Materials and Drug Delivery Systems

用于开发新型眼科材料和药物输送系统的界面控制和操纵

基本信息

批准号：
197331-2013
负责人：
Sheardown, Heather
金额：
$ 2.55万
依托单位：
McMaster University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2016
资助国家：
加拿大
起止时间：
2016-01-01 至 2017-12-31
项目状态：
已结题

来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=593733
关键词：
Interfacial Control Manipulation Development New

项目摘要

With the aging population and increasing lifestyle factors, diseases of the eye have become significant burdens to the health of Canadians. Not only does eye disease impact the ability to see, it can have a significant effect on quality of life. Vision impaired patients have been shown to suffer a significantly increased incidence of depression, are admitted to nursing homes earlier, fall more often and die at a significantly younger age than the sighted population. While there have been significant advances in the development of new therapeutics, the anatomy of the eye is such that delivery of these drugs is difficult. The work in the Sheardown lab is aimed at the development of new materials based methods for ocular treatment, including for example novel drug delivery devices targeting both the front and back of the eye as well as new materials and surfaces for contact lenses, intraocular lenses and vitreous substitutes and ocular tissue engineering. The current program will use high throughput synthesis and characterization methods that have been applied to drug discovery to facilitate the development of these materials. These methods will allow us to generate and screen thousands of candidate materials compositions and identify those combinations that may have properties which would make them candidates for further development and evaluation. Materials will be screened for various applications including delivery of drugs to the front and back of the eye, as new contact lens materials, as intraocular lenses with lower complication rates and as vitreous substitutes.

随着人口老龄化和生活方式因素的增加，眼病已成为加拿大人健康的重大负担。眼病不仅会影响视力，还会对生活质量产生重大影响。研究表明，视力受损的患者患抑郁症的几率明显增加，他们住进养老院的时间更早，摔倒的次数更多，死亡的年龄也比视力正常的人要早得多。虽然新疗法的发展取得了重大进展，但眼睛的解剖结构使得这些药物的输送很困难。Sheardown实验室的工作旨在开发基于眼部治疗的新材料方法，包括例如针对眼睛前部和后部的新型药物输送装置，以及隐形眼镜、人工晶状体和玻璃体替代品以及眼部组织工程的新材料和表面。目前的项目将使用高通量合成和表征方法，这些方法已经应用于药物发现，以促进这些材料的开发。这些方法将使我们能够生成和筛选数千种候选材料组合，并确定那些可能具有进一步开发和评估候选特性的组合。将筛选各种应用的材料，包括将药物输送到眼睛的前部和后部，作为新型隐形眼镜材料，作为并发症发生率较低的人工晶状体和玻璃体替代品。