SGER: Fluid Dynamics of the Aorta During Left Ventricular Assistance

提案编号： CTS-0333141主要制造商：Karen D. MAY-NEWMAN机构： 左心室辅助期间主动脉的流体动力学拟议研究的目标是通过提供使用这些装置时通过自体心脏和主动脉的3-D血流的详细信息来改进左心室辅助装置（LVAD）的设计及其与人体的整合。 本研究项目的智力优势是获得对通过心脏和非脉动LVAD的血流相互作用的基本理解，确定手术配置和主动脉吻合角度对血流异常的影响。 所提出的方法代表了一种新的范式，关于LVAD的研究，通过应用系统的分析，基于流体力学，调查这些设备与人体的相互作用。 这些研究的结果将导致进一步的问题，最佳策略，以改善连续流LVAD作为永久性设备。 本研究计划的更广泛影响是提高患者LVAD的性能和疗效，确定LVAD植入的最佳手术方法，建议恢复期间LVAD控制策略以优化结局，增加医疗保健提供者在照顾LVAD患者时所需的信息，并降低治疗充血性心力衰竭患者的成本。这项研究的结果将是最有用的外科医生，以修改植入技术;工程师，在LVAD设计和控制策略的改进;和医生治疗充血性心力衰竭患者。

PROPOSAL NO.: CTS-0333141PRINCIPAL INVESTIGATORS: KAREN D. MAY-NEWMANINSTITUTION: SAN DIEGO STATEUNIVERSITY FLUID DYNAMICS OF THE AORTA DURING LEFT VENTRICULAR ASSISTANCEThe goal of the proposed research is to improve the design of Left Ventricular Assist Devices (LVADs) and their integration into the human body by providing detailed information on the 3-D blood flow through the native heart and aorta when using these devices. The intellectual merits of this research program are to gain a fundamental understanding of the interaction of flow through the heart and nonpulsatile LVADs, establish the effect of surgical configuration and aortic anastomosis angle on flow abnormalities. The proposed approach represents a new paradigm regarding the study of LVADs, through application of a systematic analysis based on fluid mechanics to investigate the interaction of these devices with the human body. The findings of these studies will lead to further questions about the optimal strategies to improve continuous flow LVADs as permanent devices. The broader impacts of this research program are to improve the performance and efficacy of LVADs for patients, identify optimal surgical methods for LVAD implantation, suggest strategies for LVAD control during recovery that optimize outcome, add to the information health care providers need in caring for LVAD patients and decrease the cost of treating congestive heart failure patients. The results of this research will be most useful to surgeons, to modify implantation techniques; to engineers, for improvements in LVAD design and control strategies; and to physicians treating patients suffering from congestive heart failure.