Conference: Thrombospondins and other Modulatory Adhension Molecules in Tissue Organization and Homeostasis to be held June 5-10, 2004 in Pine Mountain, Georgia.

这是一个FASEB会议，题为“组织组织和稳态中的血小板反应蛋白和其他调节粘附分子”，将于2004年6月5-10日在格鲁吉亚松山的卡拉威花园举行。调节性粘附分子是细胞外基质（ECM）的组分，其在器官发生期间或在成人组织中由细胞特异性产生。这些蛋白质调节细胞行为、细胞相互作用和ECM组装。然而，由于其多样性和组织特异性功能，了解其细胞和分子作用机制带来了特殊的挑战。会议将具有以下智力价值：1）将研究人员聚集在一起，研究调节粘附分子的不同功能，采用不同的方法，以激发新的跨学科方法，并对其特性进行全面的机械理解; 2），在沟通的最新进展，了解结构和功能的过程中，调节粘附分子调节细胞运动，在发育和成人组织中的细胞信号传导和细胞相互作用;它们在ECM组装的复杂回路中的作用以及通过细胞外蛋白水解的ECM周转，特别是心血管和结缔组织。会议将包括正式会谈，讨论和海报会议，并为非正式互动提供绝佳机会。与会者将包括主要研究人员，博士后研究人员和研究生。31%的受邀发言人和33%的会议主席是女性; 55%的发言人是会议新人。在强调调节粘附分子在不同生物系统中的功能，并提供一个难得的机会，为最新的和综合的角度对研究的广度和深度在这个快速增长的领域，这次会议将有广泛的影响研究活动和思想领域的ECM生物学，细胞相互作用和组织组装，并将刺激沟通，合作和协同作用，以及未来研究的新方向。

This is a FASEB conference entitled "Thrombospondins and otherModulatory Adhesion Molecules in Tissue Organization and Homeostasis", to be held atCallaway Gardens, Pine Mountain, Georgia, June 5-10, 2004. Modulatory adhesion molecules are components of the extracellular matrix (ECM) that are specifically produced by cells during organogenesis or in adult tissues. These proteins regulate cell behavior, cell interactions, and ECM assembly. However, understanding their cellular and molecular mechanisms of action poses special challenges because of their diversity and tissue-specific functions. The conference will have intellectual merit: 1) in bringing together reseachers studying distinct functions of modulatory adhesion molecules, with different methodologies, in order to stimulate new interdisciplinary approaches and to develop a full mechanistic understanding of their properties; 2), in communicating recent advances in understanding the structural and functional processes by which modulatory adhesion molecules regulate cell motility, cell-signaling and cell interactions in development and in adult tissues; their roles in complex circuitries of ECM assembly and ECM turnover by extracellular proteolysis, with special reference to cardiovascular and connective tissues. The meeting will include formal talks, discussions and poster sessions and provide excellent opportunities for informal interactions. Attendees will include principal investigators, postdoctoral researchers and graduate students. 31% of the invited speakers and 33% of the session chairs are women; 55% of the speakers are new to the meeting. In highlighting the functions of modulatory adhesion molecules in different biological systems and providing a rare opportunity for an up-to-date and integrated perspective on the breadth and depth of reseach in this rapidly-growing area, this conference will have broad impact on research activities and thinking in the fields of ECM biology, cell interactions and tissue assembly and will stimulate communication, collaboration and synergy, and new directions for future research.