CAREER: Development of Chiral Nucleophilic Carbenes for Use in Organic Synthesis

罗维斯教授正在开发一种从氨基酸衍生的手性卡宾家族，它将手性放置在卡宾碳的近端。目标手性三唑亚甲基卡宾将在Stetter反应和其他亲核催化过程中作为亲核催化剂进行探索。罗维斯教授还将评估这些卡宾作为配体在新的反应流形中修饰过渡金属的反应性的行为，包括Rh卡宾络合物激活酸性C-H键和直接激活酸性X-H键(X=N、O等)。由刘易斯碱性金属络合物。罗维斯教授将在有机化学课程中引入概念图，特别是针对非化学家提高理解和表现的目标。通过这个职业奖项，有机和高分子化学项目支持科罗拉多州立大学化学系托米斯拉夫·罗维斯教授的教学和研究计划。罗维斯教授正在开发一类新的化合物，旨在调解各种类型的有机分子的选择性转化。这些研究将为构建更复杂的有机结构提供新的有效方法，为合成具有期望的化学或生物活性的化合物提供强有力的工具。通过将概念图引入有机化学课程，ROVIS教授将利用这项技术的力量，利用图形图像来说明相关主题之间的联系，以加强非化学学科的学生的理解和表现。ROVIS教授不是简单地将概念图作为一种评估工具，而是积极地让学生参与教学过程，使他们能够在其他学习中应用概念图。

Professor Rovis is developing a family of chiral carbenes, derived from amino acids, which place chirality proximal to the carbene carbon. The target chiral triazolylidene carbenes will be explored as nucleophilic catalysts in the Stetter reaction and other nucleophile catalyzed processes. Professor Rovis will also assess the behavior of these carbenes as ligands to modify the reactivity of transition metals in new reaction manifolds, including activation of acidic C-H bonds by rhodium carbene complexes and the direct activation of acidic X-H bonds (X = N, O, etc.) by Lewis basic metal complexes. Professor Rovis will introduce concept mapping to the organic chemistry curriculum, particularly targeting enhanced understanding and performance by non-chemists.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the teaching and research program of Professor Tomislav Rovis, of the Department of Chemistry at Colorado State University. Professor Rovis is developing a novel class of compounds designed to mediate selective transformations of various types of organic molecules. These studies will lead to the development of new and effective methods for the construction of more complex organic structures, providing powerful tools for the synthesis of compounds displaying desired chemical or biological activity. By introducing concept mapping to the organic chemistry curriculum, Professor Rovis will exploit the power of this technique, in which graphic images are used to illustrate connections between related topics, to enhance understanding and performance by students from non-chemical disciplines. Rather than simply using concept mapping as an assessment tool, Professor Rovis will actively involve students in the instructional process, empowering them to apply concept mapping in their other studies.