Intelligent Glucose Microsensor Array with Integrated Electrochemical Actuation System

基于水电解的电化学驱动方法用于实现三个新的功能：一点自校准（零点），线性检测范围的扩展，并增加灵敏度。在葡萄糖微传感器周围集成电化学激励系统，可以建立两种氧微环境（缺氧和恒氧）。这两种微环境对酶促反应动力学（葡萄糖氧化酶反应的氧依赖性）的影响有望提供新的功能。电流型葡萄糖微传感器采用集成电路技术制作在柔性聚酰亚胺基板（Kapton或Upilex）上。 具体目标是（1）优化器件结构（微传感器和微致动器的几何形状）和致动信号（电化学电流的幅度和持续时间）以获得新的功能，（2）基于随机算法开发智能校准器，以及（3）实现阵列以提高可靠性。PI在密苏里大学罗拉分校（UMR）的电气计算机工程和生物科学系联合任命。PI的主要职责是通过跨学科的研究活动和来自两个部门的学生的教育来弥合两个学科之间的差距。校园内的少数民族工程计划（MEP）包括提供新生/转学奖学金，举办职业和教育机会研讨会，并赞助少数民族工程学生组织。UMR运行妇女在工程和科学方案（威斯），并支持一个女工程学生组织，以增加女性毕业生进入我国技术劳动力的人数。

The electrochemical actuation method based on water electrolysis is used to achieve three novel functionalities; one-point self-calibration (zero-point), extension of linear detection range, and increase in sensitivity. Two kinds of oxygen microenvironments (oxygen-depletion and constant oxygen) can be established by using an integrated electrochemical actuation system around the glucose microsensor. The effect of these two microenvironments on the enzymatic reaction kinetics (oxygen dependency of glucose oxidase reaction) is expected to provide the novel functionalities. The amperometric glucose microsensors are fabricated on a flexible polyimide substrate (Kapton or Upilex ) using integrated circuit technology. The specific objectives are (1) optimization of device structure (geometries of microsensor and microactuator) and actuation signals (magnitude and duration of electrochemical current) to obtain the novel functionalities, (2) development of a smart calibrator based on the stochastic algorithm, and (3) implementation of array to improve reliability.The PI has a joint appointment in the Departments of Electrical & Computer Engineering and Biological Sciences at the University of Missouri-Rolla (UMR). The primary responsibility of the PI is to bridge the gap between the two disciplines through interdisciplinary research activities and education of the students from both departments. The on-campus Minority Engineering Program (MEP) includes offering of freshman/transfer scholarship, hosting seminars on career and educational opportunities, and sponsoring minority engineering student organizations. UMR runs Women in Engineering and Science Program (WIES) and supports a female engineering student organization to increase the number of female graduates entering our nation's technical workforces.