Polymeric Metal Complexes as Multifunctional Molecular Probes and Responsive Drug Delivery Vectors

0402212 Fraser智力优势：聚合物金属络合物（PMC）是一类新型多功能生物材料，在成像剂和药物递送载体中结合了联合收割机检测、保护、靶向、触发释放和降解功能。 分子量和结构控制（即生物配体呈现的化合价）可通过活性聚合获得。 研究了以联吡啶（bpy）和B-二酮为配体的金属配合物的发光和刺激响应性。 用前列腺特异性膜抗原的抗体标记的发光Ru tris（bpy）PEG-PEI材料作为用于敲除雄激素受体的短干扰RNA递送剂（其被认为对疾病进展至关重要）是令人感兴趣的。 LDV、RGD和金属PLA-PEG的其他粘附肽生物缀合物被设计用作靶向白细胞的分子探针和抗炎药物递送剂。 Ru PLA-PAA系统用于成像、粘膜粘附药物递送和多功能光动力学治疗的模型。 PMC生物材料的这些许多用途也通过对它们在受控和更复杂的生物条件下的光学、纳米级自组装和降解特性的基础研究而得到推进。更广泛的影响：小组和协作团队成员从本科生到教师，通常包括性别，种族和地理少数群体。 跨学科研究通过出版物和演讲对科学的贡献通过大学和社区的众多活动得到加强。 这些措施包括指导有前途的年轻科学家，建立跨学科知识交流的基础设施;通过举办实验室参观和在公共论坛上发言，向非科学家传达科学发现的重要性和兴奋。 潜在的技术优势是在分子成像，药物输送，传感，催化和光子材料。

0402212FraserIntellectual Merit: Polymeric metal complexes (PMCs) are a new class of multifunctional biomaterials that combine detection, protection, targeting, triggered release and degradation functions in imaging agents and drug delivery vectors. Molecular weight and architectural control (i.e. valency of bio-ligand presentation) are attainable by living polymerization. Luminescent and stimuli responsive metal complexes with bipyridine (bpy) and B-diketonate macroligands are investigated. Luminescent Ru tris(bpy) PEG-PEI materials tagged with antibodies to prostate specific membrane antigen are of interest as short interfering RNA delivery agents for knock out of the androgen receptor (which is believed to be critical for disease progression). LDV, RGD and other adhesion peptide bioconjugates of metal PLA-PEGs are designed for use as molecular probes targeting leukocytes and as anti-inflammatory drug delivery agents. Ru PLA-PAA systems are generated for imaging, mucoadhesive drug delivery, and models for multifunctional photodynamic therapeutics. These many uses for PMC biomaterials are also advanced by fundamental studies of their optical, nanoscale self-assembly, and degradation properties under both controlled and more complex biological conditions. Broader Impacts: The group and collaborative team members range from undergraduates to faculty, and often include gender, racial, and geographic minorities. Contributions of the interdisciplinary research to science through publications and presentations are augmented by numerous activities in the university and community. These include mentoring promising young scientists, building infrastructure for interdisciplinary intellectual exchange; and conveying the importance and excitement of scientific discovery to non-scientists by hosting lab visits and speaking in public forums. Potential technological benefits are in molecular imaging, drug delivery, sensing, catalysis, and photonic materials.