FASEB Conference: Post-transcriptional Control of Gene Expression: Mechanisms of mRNA Decay, to be held 2004 in Tucson, AZ

FASE B夏季研究会议题为“基因表达的转录后控制：信使核糖核酸衰变的机制”，将于2004年6月26日至7月1日在亚利桑那州图森举行。信使核糖核酸的周转是基因表达的一个关键但经常被忽视的调节器，因为信使核糖核酸的稳定性决定了它的最终稳定水平。此外，程序性不稳定性是抑制基因表达的重要机制。此外，人们越来越认识到，大多数生物体都采用了对mRNA质量进行监测的手段，以确保只有“合适”的转录本才能离开细胞核并被翻译。有针对性的信使核糖核酸周转是这个过程中不可或缺的一部分。最后，新发现的反义调控手段，包括RNA干扰，依赖于选择性的mRNA周转来实现其生物学后果。由于所有这些原因，信使核糖核酸的周转引起了更广泛的生命科学界的极大兴趣。本次会议的目标是探索在细胞和分子水平上支持mRNA周转的普遍过程的机制。这次会议将集中在原核生物和真核生物中的信使核糖核酸衰退。将涵盖的主题包括原核生物和真核生物的多功能核糖核酸酶、RNA质量控制、信使核糖核酸结合蛋白在调节信使核糖核酸稳定性中的作用、信使核糖核酸衰变与疾病、信使核糖核酸干扰和全基因组信使核糖核酸周转的方法。

The FASEB Summer Research conference entitled "Post-transcriptional control of gene expression: mechanisms of mRNA decay" will be held June 26-July1, 2004, in Tucson, AZ. Turnover of mRNA is a key but frequently unrecognized regulator of gene expression as the stability of an mRNA dictates its ultimate steady-state level. Moreover, programmed instability is an important mechanism of repressing gene expression. In addition, it is increasingly recognized that most organisms employ means of surveillance of mRNA quality to ensure that only "fit" transcripts exit the nucleus and are translated. Targeted mRNA turnover is integral to this process. Finally, newly discovered means of antisense regulation, including RNA interference, rely on selective mRNA turnover for their biological consequences. For all these reasons, mRNA turnover is attracting great interest from the broader life sciences community. The goal of this meeting is to explore the mechanisms that underpin the universal process of mRNA turnover, at both the cellular and molecular levels. This conference will focus on mRNA decay in both prokaryotic and eukaryotic organisms. The topics to be covered include the multifunctional ribonucleases of prokaryotes and eukaryotes, RNA quality control, the role of mRNA binding proteins in mediating mRNA (in)stability, mRNA decay and disease, RNA interference and genome-wide approaches to mRNA turnover.