Development of Rhodium Catalyzed [4+2+2] Cycloaddition Reactions in Organic Synthesis

本研究的重点是开发将非环起始物质转化为八元环的方法学。我们将研究Rh催化的二烯乙炔[4+2+2]环异构化反应的范围和机理，并将研究结果扩展到包括其他底物。此外，还将探索铑催化剂体系的性质。凭借这一奖项，有机和高分子化学计划将支持德克萨斯大学加尔维斯顿分校药理学和毒理学系的Scott R.Gilbertson博士的研究。吉尔伯森博士将把工作重点放在开发合成八元环的催化方法上，这类化合物很难用标准的合成方法制备。就更广泛的影响而言，该项目具有发展绿色化学和培养研究生的潜力。

The focus of this research is the development of methodology for the transformation of acyclic starting materials into eight member rings. The scope and mechanism of the rhodium catalyzed [4+2+2] cycloisomerization reaction of dienynes will be examined and the findings extended to include other substrates. Further, the nature of the rhodium catalyst system will be explored.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Scott R. Gilbertson of the Department of Pharmacology & Toxicology at the University of Texas Medical Branch at Galveston. Dr. Gilbertson will focus his work on developing catalytic methodology for the synthesis of eight member rings, a class of compounds difficult to prepare by standard synthetic methods. In terms of broader impacts, the project has potential for developing green chemistry and for the training of graduate students.