Katalytische Eigenschaften von neuen Pyridin-basierenden Ruthenium-Pincer-Komplexen

在本项目中，我们要研究钳形配体稳定的钌配合物对羰基化合物的氢化和醇与胺或醇的缩合偶联的催化性能。开发“绿色”环境友好、高效和经济上有吸引力的过程是化学最重要的目标之一。理想地，应该开发具有根本上新的催化原理的新反应。Milstein等人描述的钌钳形配合物对许多具有重要工业意义的新反应显示出催化活性，包括醇脱氢形成酯和H2，胺与醇催化偶联产生酰胺和H2，以及在温和条件下酯氢化成醇。基于相关化合物的可行方法和新的潜在应用的开发是非常期望的。这是可能的，选择性改性的催化剂将导致更高的速率，并可以提供有关这些新的反应机理信息。为了扩大这些反应的范围，我们设想开发一种用于羰基化合物氢化的通用方法，这将是合成高价值化合物的有吸引力的方法。基于这些研究，计划开发迄今为止前所未有的催化对映选择性方法。为此，将合成新的手性钳形配合物并研究其在对映选择性催化中的应用。

In this project we want to investigate the catalytic properties of pincer ligand stabilized ruthenium complexes towards hydrogenation of carbonyl compounds and dehydrogenative coupling of alcohols with amines or alcohols. The development of "green" environmentally friendly, efficient, and economically attractive processes is one of the most important goals of chemistry. Ideally new reactions with fundamentally new catalytic principals should be developed. The ruthenium pincer complexes described by Milstein et al. show catalytic activity towards a number of novel reactions of great industrial importance, including dehydrogenation of alcohols to form esters and H2, the catalytic coupling of amines with alcohols to produce amides and H2, and the hydrogenation of esters to alcohols under mild conditions. The development of viable methods and new potential applications based on related compounds is very desirable. It is likely that selective modification of the catalyst will result in higher rates and could give mechanistic information about these novel reactions. To extend the scope of these reactions, we envisage to develop a general method for the hydrogenation of carbonyl compounds, which would be an attractive method for the synthesis of high-value compounds. Based on these investigations it is planned to develop catalytic enantioselective processes, which are unprecedented so far. For this purpose new chiral pincer complexes will be synthesized and studied in enantioselective catalysis.