Thermochemical and Mechanistic Studies of Sm(II)-Based Reagents

有了这个更新的建议，有机和高分子化学计划继续支持教授罗伯特A。宾夕法尼亚州伯利恒利哈伊大学化学系的花朵。 该研究将扩展PI对钐基试剂反应机理的研究。 系统地研究溶剂、配体和添加剂对这些重要合成试剂的反应性的影响，将产生关于它们的化学的有价值的基础数据。 由于每年有近100篇关于SmI2在合成中的应用的论文，这些研究将为合成化学家提供许多有价值的信息，并允许扩展到新的应用，这些研究有望导致对有机化学中镧系元素催化机理的广泛理解。 在这方面，PI将开发一个研究生课程的镧系元素在有机合成中的应用，利用这项研究的结果和最近的文献。 这项工作将为学生提供重要的专业准备，在一个重要的和新兴的领域，桥梁有机和无机化学。

With this renewal proposal the Organic and Macromolecular Chemistry Program continues its support for the work of Professor Robert A. Flowers of the Department of Chemistry at Lehigh University in Bethlehem, PA. The research will extend the PI's research on the mechanism of reaction of samarium-based reagents. A systematic study of the influence of solvents, ligands, and additives on the reactivity of these important synthetic reagents will yield valuable fundamental data on their chemistry. Since there are nearly 100 papers/yr on the use of SmI2 in synthesis, the proposed investigations will provide synthetic chemists with much valuable information and allow extensions into new applications.These studies are expected to lead to broad understanding of the mechanism of lanthanide catalysis in organic chemistry. In this connection, the PI will develop a graduate course on the applications of lanthanides in organic synthesis utilizing results from this research and from the recent literature. This work will provide important professional preparation for students in an significant and emerging field that bridges organic and inorganic chemistry.