Synthesis of Divinylcyclopropanes via Organoiron Methodology and Subsequent Cope rearrangement

本研究的重点涉及使用铁羰基助剂介导制备顺式-二乙烯基环丙烷，其将重排得到1，4-环庚烯。 此外，（戊烯二基）铁络合物的稳定性将被用于化学修饰顺式-二乙烯基环丙烷的前体，该方法将被应用于天然产物（+）-羟基克罗酮，（+）-cladantherone和（+）-clavularin A的合成。马奎特大学化学系的唐纳森说。 唐纳森博士将把工作重点放在使用铁介导的合成，然后重排化学制备七元环。所得中间体将用于天然产物的合成。该项目还为本科生和研究生的培训提供了一个很好的场所，并可能在制药行业产生更广泛的影响。

The focus of this research involves the use of an iron carbonyl adjunct to mediate the preparation of cis-divinylcyclopropanes that will rearrange to give 1,4-cycloheptaienes. Further, the stability of (pentenediyl)iron complexes will be utilized to chemically modify precursors to the cis-divinylcyclopropanes and the methodology will be applied to the synthesis of the natural products (+)-hydroxycolorenone, (+)-cladantholide and (+)-clavularin A.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. William A. Donaldson of the Department of Chemistry at the Marquette University. Dr. Donaldson will focus his work on using iron-mediated synthesis followed by rearrangement chemistry to prepare seven membered rings. The resulting intermediates will be used for the synthesis of natural products. The project also provides an excellent venue for the training of undergraduate and graduate students and could have broader impact in the pharmaceutical industry.