SBIR Phase II: Novel Bioaerosol Concentrator/Sampler for Enhanced Biosensor Performance

该小型企业创新研究（SBIR）第二阶段项目建议开发一种强大的，通用的，前端的生物采样器，当与湿式或干式生物检测器结合时，将导致更准确和快速地检测有害的空气传播生物制剂。 虽然目前大多数系统需要在流体中输送样品进行分析，但新兴的干式检测技术有助于近实时检测，减少采样错误并允许无人值守操作。 在第一阶段开发的原型生物采样器在干式收集模式下表现出非常高的效率。 第二阶段项目的目标如下：（a）优化范围低端粒子的采样性能（2微米），（B）保持收集的生物体的高生物活力，（C）在湿或干模式下有效发挥作用，（d）展示自清洁/净化功能，（e）评估更大空气体积的可扩展性，最后，（f）展示综合生物检测系统的整体性能得到提高。 该项目的商业应用将在国土安全和公共安全领域。拟议的技术将提高目前部署的探测系统和目前正在开发的先进生物探测器的性能。 其他应用将在环境监测和工业空气质量。

This Small Business Innovation Research (SBIR) Phase II project proposes to develop a robust, generic, front-end, bio-sampler that when combined with either a wet or dry biological detector, will result in more accurate and rapid detection of hazardous airborne biological agents. While most current systems require samples to be delivered in a fluid for analysis, emerging dry detection technologies facilitate near-real time detection, reduce sampling errors and allow for unattended operation. The prototype bio-sampler developed in Phase I demonstrated very high efficiency in the dry collection mode. This Phase II project has the following objectives: (a) to optimize sampling performance for particles at the low end of the range (2 micron), (b) to maintain high bio-viability of collected organisms, (c) to function efficiently in the wet or the dry mode, (d) to demonstrate self-cleaning / decontamination features, (e) to evaluate scalability to larger air volumes and, finally, (f) to demonstrate enhanced overall performance in an integrated biological detection system. The commercial application of this project will be in the area of homeland security and public safety. The proposed technology will enhance the performance of both the detection systems that are presently deployed and that of the advanced biological detectors that are currently under development. Additional applications will be in the monitoring of the environment and of industrial air quality.