Collaborative Research: Aortic Aneurysm Pathobiology

本项目旨在对腹主动脉瘤(AAA)的病理生物学行为进行详细研究。研究人员计划从患者的CT扫描中构建单独的AAA模型，并使用这些模型来分析和表征在稳定和脉动条件下通过模型的流动模式。在该项目的下一阶段，动脉内皮细胞将被种植到模体的内壁上，并允许增殖。然后，在项目前面确定的特定流程和压力测试下对模型进行测试。最后，对细胞进行某些选定的标记物测试，这些标记物会影响动脉壁弹性和破裂的可能性。该项目提供了工程技术、分子生物学和医学的平衡整合。

Peattie0502485ABSTRACTThis project proposes a detailed investigation of the pathobiologic behavior of abdominal aortic aneurysms (AAAs). The investigators plan to construct individual phantoms of AAAs from CT scans of patients, and use the phantoms to analyze and characterize the flow patterns through the phantoms under both steady and pulsatile conditions. In the next phase of the project, arterial endothelial cells will be seeded on to the interior wall of the phantoms and allowed to multiply. Then the phantoms are tested under the specific flow and stress tests as determined earlier in the project. Finally, the cells are tested for certain selected markers which affect the arterial wall elasticity and the possibility of rupture. The project offers a balanced integration of engineering techniques, molecular biology and medicine.