Calcium phosphate bone cements for local therapy of defects of the systemically diseased bone ((02) M02)

在M2中，将开发一种糊状磷酸钙水泥（CPC）应用系统，该系统允许CPC与载药水相（水凝胶、溶液或悬浮液）结合作为核/壳结构，并对其药物释放进行表征。CPC与介孔生物活性玻璃或干凝胶（M3）组成的复合材料将进一步开发和表征其作为药物载体的应用。此外，利用CPC作为治疗性抗体载体的策略也有待开发和评估。与B1和B13合作，生成体外模拟骨溶解的3D模型。

In M2, an application system for pasty calcium phosphate cements (CPC) allowing extrusion of CPC in combination with a drug-loaded aqueous phase (hydrogel, solution or suspension) as core/shell structure is to be developed and characterized regarding drug release. The composites consisting of CPC and mesoporous bioactive glass or xerogels (M3) will be further developed and characterized with respect to their application as drug carrier. In addition, strategies for usage of the CPC as carrier for therapeutic antibodies are intended to develop and evaluate. In cooperation with B1 and B13, 3D models for in vitro simulation of osteolyses will be generated.