Influence of aetiology-adapted bone substitutes on the regulation of bone remodeling, microvascularisation and innervation in systemically diseased bone ((12) B07)

由于神经营养因子BDNF增加了骨形成细胞的活力，我们将分析释放BDNF的骨替代材料，包括纳米颗粒（PEC-NP）在植入物相关的骨折模型的毒蕈碱乙酰胆碱受体M3敲除小鼠与神经退行性表型的影响。在共培养系统中，我们将确定BDNF对材料界面处免疫细胞的影响。此外，还计划研究嘌呤能系统、硬化素中和抗体和降钙素肽家族成员是否是骨质疏松骨替代材料的合适调节剂。

Since the neurotrophic factor BDNF increases the vitality of bone forming cells, we will analyze the effect of BDNF-releasing bone substitute material including polyelectrolyte nanoparticles (PEC-NP) in an implant-associated fracture model of muscarinic acetylcholine receptor M3 knockout mice with an osteoporotic phenotype. In co-culture systems we will determine the effect of BDNF on immune cells at the interface of materials. In addition it is planned to investigate whether the purinergic system, sclerostin neutralizing antibodies and members of the calcitonin peptide family are suitable modula-tors for bone substitute materials of osteoporotic bone.