Early Life Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders

糖尿病及相关代谢紊乱的早期病因和机制

• 批准号: MC_UU_00006/2
• 负责人: Kenneth Ong
• 金额: $ 512.48万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2020
• 资助国家: 英国
• 起止时间: 2020 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MC_UU_00006%2F2
• 关键词: Early; Life; Aetiology; Mechanisms; Diabetes

The aim of this programme is to predict and prevent childhood obesity by identifying genetic, dietary and other factors that act during infancy. The specific objectives are to identify genetic factors and patterns of early infant diet and growth that predict childhood obesity, and to develop and test interventions to avoid excessive infant weight gain and childhood obesity. |Childhood obesity is a major public health problem. Research is important because 1) currently there are no proven interventions to prevent childhood obesity, 2) rates of obesity are rising even in young children, 3) childhood obesity has important consequences for childhood health and development, as well as adult health.|This research is being performed in a number of UK birth cohort studies, including close collaborations with the Avon Longitudinal Study of Parents and Children (ALSPAC), the Southampton Womens Study (SWS), and the Cambridge Baby Growth Study (MRC Epidemiology Unit & Department of Paediatrics, University of Cambridge). Candidate genetic factors for study in DNA samples collected in children are selected by in collaboration with the Sanger Institute and University of Cambridge Genetics of Energy & Metabolism (GEM) consortium. Prediction models for risk of childhood obesity and its complications will be based on collaborative studies between investigators from a wide range of UK and international birth cohort studies. |A randomised controlled trial will be performed by recruiting mothers during pregnancy to test whether education to avoid excess infant nutrient intake will prevent rapid infant weight gain and childhood obesity risk. Future targeted interventions will be developed for testing in infants and young children identified to have high risk of childhood obesity.

该计划的目的是通过确定在婴儿期起作用的遗传、饮食和其他因素来预测和预防儿童肥胖症。具体目标是确定预测儿童肥胖的早期婴儿饮食和发育的遗传因素和模式，并开发和测试干预措施，以避免婴儿体重过度增加和儿童肥胖。儿童肥胖是一个主要的公共健康问题。研究之所以重要，是因为1)目前还没有得到证实的预防儿童肥胖的干预措施，2)肥胖率甚至在幼儿中都在上升，3)儿童肥胖症对儿童的健康和发育以及成人的健康具有重要的后果。|这项研究正在进行的多项英国出生队列研究中，包括与雅芳亲子纵向研究(ALSPAC)、南安普顿妇女研究(SWS)和剑桥婴儿生长研究(剑桥大学MRC流行病学单位和儿科系)的密切合作。在收集的儿童DNA样本中研究的候选遗传因素是由桑格研究所和剑桥大学能量与新陈代谢遗传学(GEM)联盟合作挑选的。儿童肥胖及其并发症的风险预测模型将基于来自英国和国际出生队列研究的广泛研究人员之间的合作研究。|将通过招募怀孕期间的母亲进行随机对照试验，以测试避免婴儿过量营养摄入的教育是否可以防止婴儿体重迅速增加和儿童肥胖风险。未来将制定有针对性的干预措施，用于对被确定为儿童肥胖症高风险的婴幼儿进行测试。

项目成果

Shared and distinct genetic etiologies for different types of clonal hematopoiesis.

• DOI: 10.1038/s41467-023-41315-5
• 发表时间: 2023-09-08
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Brown, Derek W.;Cato, Liam D.;Zhao, Yajie;Nandakumar, Satish K.;Bao, Erik L.;Gardner, Eugene J.;Hubbard, Aubrey K.;Depaulis, Alexander;Rehling, Thomas;Song, Lei;Yu, Kai;Chanock, Stephen J.;Perry, John R. B.;Sankaran, Vijay G.;Machiela, Mitchell J.
• 通讯作者: Machiela, Mitchell J.

A multiparametric anti-aging CRISPR screen uncovers a role for BAF in protein translation

多参数抗衰老 CRISPR 筛选揭示了 BAF 在蛋白质翻译中的作用

• DOI: 10.1101/2022.10.07.509469
• 发表时间: 2022
• 作者: Breusegem S

Timing of the Infancy-Childhood Growth Transition in Rural Gambia.

冈比亚农村地区婴儿期至儿童期增长转变的时机。

• DOI: 10.17863/cam.52829
• 发表时间: 2020
• 作者: Bernstein R

Rare variants in the MECP2 gene in girls with central precocious puberty: a translational cohort study.

中枢性性早熟女孩 MECP2 基因的罕见变异：一项转化队列研究。

• DOI: 10.17863/cam.100709
• 发表时间: 2023
• 作者: Canton A

Timing of the Infancy-Childhood Growth Transition in Rural Gambia

• DOI: 10.3389/fendo.2020.00142
• 发表时间: 2020-03-24
• 期刊: FRONTIERS IN ENDOCRINOLOGY
• 影响因子: 5.2
• 作者: Bernstein, Robin M.;O'Connor, G. Kesler;Moore, Sophie E.
• 通讯作者: Moore, Sophie E.