Structure and function of the cyanobacterial color sensor Cph2

蓝藻光敏色素是一个不同的光受体家族，控制着不同的生物细胞功能，包括趋光性。在植物类型分支中典型的真诚光敏色素中，蓝藻也含有吸收绿色、紫色或蓝色光的光敏色素。聚球藻。PCC6803光感受器Cph2是一种红/远红光和蓝光传感器。它可能通过改变c-di-GMP水平来调节趋光性。我们已经分析了这两个光吸收区域的光谱特性，并开始结晶它们进行详细的分析。在这里，我们将结合两个实验室在结构和生物基础上共同工作的专业知识，来揭示两个不同的光信号是如何由一个光传感器Cph2处理和传输的机制。结构和生化信息将与生物产量相关，即趋光性和c-di-GMP水平的变化。

Cyanobacterial phytochromes are a diverse family of light receptors controlling different biological cell functions including phototaxis. Among canonical bona fide phytochromes of the well characterized plant-type clade, cyanobacteria also harbor phytochromes that absorb green, violet or blue light. The Synechocystis sp. PCC 6803 photoreceptor Cph2 is both a red/far-red and blue light sensor. It regulates phototaxis possibly via alterations in the c-di-GMP level. We have analyzed spectroscopic characteristics of the two light-absorbing domains and started to crystallize them for detailed analysis. Here, we will combine the expertise of two laboratories working together on a structural and biological base to unravel the mechanism how two different light signals are processed and transmitted by one photosensor, Cph2. Structural and biochemical information will be correlated to biological output, namely alterations in phototaxis and c-di-GMP level.